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12 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Saby George; Christopher Hoimes; Aly-Khan Lalani;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background A randomised study to assess the addition of apatorsen, an antisense oligonucleotide that inhibits Hsp27 expression, to docetaxel in patients with metastatic urothelial carcinoma (mUC) relapsed after prior platinum-based chemotherapy. Methods Multicentre, pha...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    marco zappa; Anssi Auvinen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    textabstractBackground:The European Randomised Study of Prostate Cancer Screening has shown a 21% relative reduction in prostate cancer mortality at 13 years. The causes of death can be misattributed, particularly in elderly men with multiple comorbidities, and therefor...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Joseph Neglia; Wendy Leisenring;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Survivorship: Mentoring a... (5K05CA160724-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | CANCER CENTER SUPPORT GRA... (5P30CA021765-12), NIH | EMPOWER Study: Promoting ... (5R01CA134722-05), NIH | Prediction Model: Breast ... (5R01CA136783-02), NIH | CHILDHOOD CANCER SURVIVOR... (5U24CA055727-08)

    Background: The relationship between hormone exposure and breast cancer risk in women treated with chest radiotherapy for childhood cancer is uncertain. Methods: Participants included 1108 females from the Childhood Cancer Survivor Study who were diagnosed with childhoo...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Sun Young Rha; Howard Gurney;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background In the phase 3 METEOR trial, cabozantinib improved progression-free survival (PFS), objective response rate (ORR), and overall survival (OS) versus everolimus in patients with advanced renal cell carcinoma (RCC), after prior antiangiogenic therapy. Methods Ou...

  • publication . Article . 2015
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; FULVIO RICCERI; Christine Friedenreich; Sara Olson; Veronica Setiawan; Amanda Spurdle; Anne Zeleniuch-Jacquotte; Elisabete Weiderpass;
    Publisher: Nature Publishing Group
    Project: NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01CN067001-000), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Soyfood, gene polymorphis... (5R01CA092585-05), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), NIH | DISTRIBUTION OF BODY FAT ... (3R01CA039742-11S1), NIH | Experimental Pathology (5P30CA016087-32), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | CASE-CONTROL STUDY OF POS... (5R01CA048774-04),...

    Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . 2018
    Open Access
    Authors:
    Teo, Min Yuen; Scher, Howard I.;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Summary Abiraterone acetate plus prednisone is a standard treatment option for mCRPC. The phase II SWITCH trial showed that further prostate-specific antigen (PSA) responses can be obtained in a subset of patients when prednisone was switched to dexamethasone at progres...

  • publication . Article . 2017
    Open Access English
    Authors:
    Colin B Begg; Megan S Rice; Emily C Zabor; Shelley S Tworoger;
    Publisher: Nature Publishing Group
    Project: NIH | Statistical Strategies fo... (5R01CA163251-03), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often t...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Shuji Ogino; Richard Hayes; Michael Hoffmeister; Fredrick Schumacher; Tabitha Harrison; Bette Caan; Mark Jenkins; Hermann Brenner;
    Publisher: The University of North Carolina at Chapel Hill University Libraries
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | Cancer Prevention Trainin... (5R25CA094880-12), NIH | GENETIC EPIDEMIOLOGIC STU... (5R01CA059045-04), NIH | Molecular pathological ep... (2U01CA137088-05), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), WT , NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | Ontario Registry for Stud... (3U01CA074783-09S2), NIH | AUSTRALASIAN COLORECTAL C... (5U01CA097735-05),...

    BACKGROUND: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Fotios Loupakis; Herbert I. Hurwitz; Leonard Saltz; Dirk Arnold; Axel Grothey; Quynh Lan Nguyen; Stuart Osborne; Jonathan Talbot; Stefanie Srock; Heinz-Josef Lenz;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. Methods Patie...

12 research outcomes, page 1 of 2
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