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53 research outcomes, page 1 of 6
  • publication . Article . 2017
    Open Access English
    Authors:
    Glubb, D. M.; Johnatty, S. E.; Quinn, M. C. J.; O Mara, T. A.; Tyrer, J. P.; Gao, B.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; Vergote, I.; ...
    Project: NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), NHMRC | Australasian Biospecimen ... (310670), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NHMRC | Molecular Epidemiology of... (400281), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01PC067001-001), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Australasian Biospecimen ... (628903), NHMRC | Towards cancer control: P... (199600),...

    We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic anal...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Jonathan Marchini; Daniel Vincent; Ulrike Peters; Gerhard A. Coetzee; Heike Bickeböller; Kenneth Offit; Kenneth Offit; Kenneth Offit; Dennis J. Hazelett; Sune F. Nielsen; ...
    Project: NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Administrative Core (5U19CA148127-02), NIH | Epidemiologic Studies (5U19CA148107-04), EC | RADIOGENFF (656144), NIH | Genetic Variation in the ... (5R01CA122443-06), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA081488-05), CIHR , NIH | Breast Cancer Family Regi... (1UM1CA164920-01A1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2),...

    Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    S Ken Tian; Richard J. Wong; Diego Chowell; Ian Ganly; Justin Tepe; Marc Cohen; Luc G. T. Morris; Ronald Ghossein; Leonard H. Wexler; Zaineb Nadeem; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Functionalizing recurrent... (1K08DE024774-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Towards Precision Immuno-... (1R35CA232097-01), NIH | Identifying and targeting... (1R01DE027738-01)

    Anti-tumor immunity is driven by self vs. non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that c...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Martin H. Voss; Martin H. Voss; Hossein Borghaei; William J. Geese; Charles M. Rudin; Charles M. Rudin; Natasha Rekhtman; Jennifer L. Sauter; Ai Ni; Matthew D. Hellmann; ...
    Publisher: CELL PRESS
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Hellmann et al. examine non-small-cell lung cancers treated with combined PD-1 and CTLA-4 blockade using whole-exome sequencing and find that high tumor mutation burden is the strongest feature associated with improved objective response, durable benefit, and progressio...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Daniel L.J. Thorek; Anuja Ogirala; Jan Grimm; Bradley J. Beattie;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (5R25CA096945-07), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Cerenkov-emission based n... (5R01EB014944-04)

    In the era of personalized medicine, there is an urgent need for in vivo techniques able to sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely used; however, radioactive decay is a physical constant, and its signal is indepen...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, G.; Bogliolo, M.; Catucci, I.; Caleca, L.; Lasheras, S. V.; Pujol, R.; Kiiski, J. I.; Muranen, T. A.; Barnes, D. R.; Dennis, J.; ...
    Project: NIH | Genome-wide association s... (5R01CA142996-03), NHMRC | Epidemiology of Chronic D... (209057), NIH | Targeting Kinesin Family ... (5R01CA214545-02), NIH | NRG ONCOLOGY NETWORK GROU... (3U10CA180868-02S2), NIH | SPORE in Breast Cancer (5P50CA058223-12), NIH | Life Course Cancer Epidem... (1UM1CA176726-01), NIH | Hormonal Factors in Invas... (5K07CA092044-02), EC | RISK FACTORS CANCER (294576), NIH | Identifying and validatin... (5R01CA176785-05), NIH | MOUSE GENETICS (2P30CA008748-43),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Patrycja Gazinska; Farzana Noor; Pau Castel; Jelmar Quist; Jelmar Quist; Erika Francesch-Domenech; Gianmaria Liccardi; Albert Gris-Oliver; Maurizio Scaltriti; Simone Filosto; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant mammary epithelial cel...

  • publication . Article . 2019
    Open Access English
    Authors:
    Hammel, P.; Kindler, H. L.; Reni, M.; Van Cutsem, E.; Macarulla, T.; Hall, M. J.; Park, J. O.; Hochhauser, D.; Arnold, D.; Oh, D-Y; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    BACKGROUND: Patients with metastatic pancreatic cancer (mPC) often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, Phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Elvira Mass; Elvira Mass; Christian Schulz; Andreas Margraf; Hellen Ishikawa-Ankerhold; Stefan Hutter; R Schuchert; Jon Frampton; Simon Yona; Raffael Thaler; ...
    Project: NIH | Macrophage development an... (1R01AI130345-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely und...

  • publication . Article . 2016
    Open Access English
    Authors:
    Francesmary Modugno; Robert A. Vierkant; Andrew Berchuck; Joellen M. Schildkraut; Jenny Chang-Claude; Jenny Chang-Claude; Rikki Cannioto; Satoyo Hosono; Lisa E. Paddock; Roberta B. Ness; ...
    Project: NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN055424-007), NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01PC067001-001),...

    Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnosti...

53 research outcomes, page 1 of 6