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3 research outcomes, page 1 of 1
  • publication . Article . 2017
    Open Access English
    Authors:
    Pamela Moody; Timour Baslan; Timour Baslan; Timour Baslan; Lee Spraggon; Larry Norton; Linda Rodgers; Felipe C. Geyer; Arnaud Da Cruz Paula; Arnaud Da Cruz Paula; ...
    Project: NIH | CSHL CANCER CENTER SUPPOR... (3P30CA045508-08S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer cells. This intratumor genetic heterogeneity poses a substantial challenge for the implementation of precision medicine. Single-cell genomics constitutes a powerful approach to...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Piro Lito; Piro Lito; Gouri Nanjangud; Trang Thi Mai; Yaohua Xue; Yaohua Xue; G. J. Riely; Ulrika Stierner; Alberto Vides; Fabiola Cechhi; ...
    Project: NIH | Elucidating the regulatio... (5K08CA191082-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30)

    The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAFamp) in patient-derived tumor xenografts (PDXs) that were treated with a dir...

  • publication . Article . 2012
    Open Access English
    Authors:
    Samuel L. Rice; John Wongvipat; Charles L. Sawyers; Michael J. Evans; Jason P. Holland; Jason S. Lewis;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel posi...

3 research outcomes, page 1 of 1