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10 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Piro Lito; Piro Lito; Gouri Nanjangud; Trang Thi Mai; Yaohua Xue; Yaohua Xue; G. J. Riely; Ulrika Stierner; Alberto Vides; Fabiola Cechhi; ...
    Project: NIH | Elucidating the regulatio... (5K08CA191082-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30)

    The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAFamp) in patient-derived tumor xenografts (PDXs) that were treated with a dir...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Omar Abdel-Wahab; Andrei V. Krivtsov; Neil L. Kelleher; Ari Melnick; Ouathek Ouerfelli; Benjamin H. Durham; Elisa de Stanchina; Gil Blum; Heike Keilhack; Alan Chramiec; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Investigation of the Role... (1F31CA180642-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Profile substrates and in... (1R01GM096056-01)

    The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epig...

  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    Eric C. Sorenson; Hebroon Obaid; Jedd D. Wolchok; Tianhua Guo; Ferdinand Rossi; Jianda Yuan; Shan Zeng; Rachel Popow; Lee M. Ocuin; James P. Allison; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A Mouse Model for Human G... (5R01CA102774-04), NIH | PI 3-KINASE AND KIT RECEP... (5R01HL055748-03), NIH | Molecular Mechanisms in G... (7R01CA102613-12)

    Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism is believed to depend predominantly on the inhibition of KIT-driven signals for tumor-cell survival and prolife...

  • publication . Article . 2012
    Open Access English
    Authors:
    Samuel L. Rice; John Wongvipat; Charles L. Sawyers; Michael J. Evans; Jason P. Holland; Jason S. Lewis;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel posi...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Meera Hameed; Ryma Benayed; Jaclyn F. Hechtman; Ahmet Zehir; Meera Prasad; Hongxin Zhang; Laetitia Borsu; Nikolaus Schultz; David Barron; Sarah Phillips; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically-de...

  • publication . Article . 2017
    Open Access English
    Authors:
    Pamela Moody; Timour Baslan; Timour Baslan; Timour Baslan; Lee Spraggon; Larry Norton; Linda Rodgers; Felipe C. Geyer; Arnaud Da Cruz Paula; Arnaud Da Cruz Paula; ...
    Project: NIH | CSHL CANCER CENTER SUPPOR... (3P30CA045508-08S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer cells. This intratumor genetic heterogeneity poses a substantial challenge for the implementation of precision medicine. Single-cell genomics constitutes a powerful approach to...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    S Ken Tian; Richard J. Wong; Diego Chowell; Ian Ganly; Justin Tepe; Marc Cohen; Luc G. T. Morris; Ronald Ghossein; Leonard H. Wexler; Zaineb Nadeem; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Functionalizing recurrent... (1K08DE024774-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Towards Precision Immuno-... (1R35CA232097-01), NIH | Identifying and targeting... (1R01DE027738-01)

    Anti-tumor immunity is driven by self vs. non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that c...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Daniel L.J. Thorek; Anuja Ogirala; Jan Grimm; Bradley J. Beattie;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (5R25CA096945-07), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Cerenkov-emission based n... (5R01EB014944-04)

    In the era of personalized medicine, there is an urgent need for in vivo techniques able to sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely used; however, radioactive decay is a physical constant, and its signal is indepen...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Patrycja Gazinska; Farzana Noor; Pau Castel; Jelmar Quist; Jelmar Quist; Erika Francesch-Domenech; Gianmaria Liccardi; Albert Gris-Oliver; Maurizio Scaltriti; Simone Filosto; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant mammary epithelial cel...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Jessica J. Tao; Ying Zhang; David M. Hyman; David M. Hyman; Nathaniel A. Outmezguine; Na Na; Gideon Bollag; Huiyong Zhao; Rory Mcgriskin; Chao Zhang; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Studies on oncoprotein-in... (5R35CA210085-02), NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | Cancer Chemotherapy Train... (5T32CA009207-29)

    Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can function as active monomers1. Current RAF inhibitors are monomer selective, they potently inhibit BRAF V600 monomers but t...

10 research outcomes, page 1 of 1