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2 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2019
    Open Access
    S Ken Tian; Richard J. Wong; Diego Chowell; Ian Ganly; Justin Tepe; Marc Cohen; Luc G. T. Morris; Ronald Ghossein; Leonard H. Wexler; Zaineb Nadeem; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Functionalizing recurrent... (1K08DE024774-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Towards Precision Immuno-... (1R35CA232097-01), NIH | Identifying and targeting... (1R01DE027738-01)

    Anti-tumor immunity is driven by self vs. non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that c...

  • publication . Article . Other literature type . 2017
    Open Access English
    Piro Lito; Piro Lito; Gouri Nanjangud; Trang Thi Mai; Yaohua Xue; Yaohua Xue; G. J. Riely; Ulrika Stierner; Alberto Vides; Fabiola Cechhi; ...
    Project: NIH | Elucidating the regulatio... (5K08CA191082-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30)

    The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAFamp) in patient-derived tumor xenografts (PDXs) that were treated with a dir...

2 research outcomes, page 1 of 1