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10 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Yaohua Xue; Luciano Martelotto; Timour Baslan; Alberto Vides; Martha Solomon; Trang Thi Mai; Neelam Chaudhary; Greg J Riely; Bob T Li; Kerry Scott; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Elucidating the regulatio... (5K08CA191082-02)

    The principles governing evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of BRAF amplification (BRAFamp) in patient-derived tumor xenografts (PDX) treated with a direct ERK inhibitor, alone or in combi...

  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    Tianhua Guo; Charlotte Ariyan; James P. Allison;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PI 3-KINASE AND KIT RECEP... (5R01HL055748-03), NIH | A Mouse Model for Human G... (5R01CA102774-04), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Molecular Mechanisms in G... (7R01CA102613-12)

    Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism is believed to depend predominantly on the inhibition of KIT-driven signals for tumor-cell survival and prolife...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Barbara Spitzer; Paul M Thomas; Andrei Krivtsov; Benjamin Durham; Ouathek Ouerfelli; Richard Koche; Young Rock Chung;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Investigation of the Role... (1F31CA180642-01), NIH | Profile substrates and in... (1R01GM096056-01)

    The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epig...

  • publication . Article . 2012
    Open Access
    Authors:
    Jason Lewis; Jason P. Holland; Samuel Rice;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    A non-invasive technology that quantitatively measures the activity of oncogenic signaling pathways could broadly impact cancer diagnosis and treatment using targeted therapies. Here we describe the development of 89Zr-desferrioxamine transferrin (89Zr-Tf), a novel posi...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Wei Yang; Ken-Wing Lee; Raghvendra M. Srivastava; Fengshen Kuo; Chirag Krishna; Diego Chowell; Vladimir Makarov; Douglas Hoen; Martin G. Dalin; Leonard Wexler; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Identifying and targeting... (1R01DE027738-01), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Functionalizing recurrent... (1K08DE024774-01), NIH | Towards Precision Immuno-... (1R35CA232097-01)

    Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens tha...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Fara Brasó Maristany; Simone Filosto; Violeta Serra; Pascal Meier; Maggie Chon U Cheang; Richard Buus; Pau Castel; Anita Grigoriadis; Gris-Oliver A;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant mammary epithelial cel...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Thorek, Daniel LJ; Ogirala, Anuja; Beattie, Bradley J; Grimm, Jan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Cerenkov-emission based n... (5R01EB014944-04), NIH | Molecular Imaging: Traini... (5R25CA096945-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    In the era of personalized medicine there is an urgent need for in vivo techniques able to sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely used, but radioactive decay is a physical constant and signal is independent of bio...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Na Na; qing chang; ZHAN YAO;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | Studies on oncoprotein-in... (5R35CA210085-02), NIH | Cancer Chemotherapy Train... (5T32CA009207-29)

    Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can function as active monomers1. Current RAF inhibitors are monomer selective, they potently inhibit BRAF V600 monomers but t...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Jaclyn Hechtman; Pedram Razavi; Maeve Lowery; Darren Feldman; Sumit Middha; Hyunjae (Ryan) Kim; Angelica Ochoa; Jonathan Coleman; Dalicia Reales; Bernard Bochner; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically-de...

  • publication . Article . 2017
    Open Access
    Authors:
    Luciano G. Martelotto; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | CSHL CANCER CENTER SUPPOR... (3P30CA045508-08S1)

    A method enabling copy-number analysis of single cells from formalin-fixed paraffin-embedded samples is described, validated and applied to analyze samples of synchronous ductal carcinoma in situ and invasive breast carcinoma. A substantial proportion of tumors consist ...

10 research outcomes, page 1 of 1
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