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8 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Bobbie Pelham-Webb; Nipun Verma; Federico González Grassi; Danwei Huangfu;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output are difficult to establish owing to challenges in distinguish...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Craig M. Bielski; Ahmet Zehir; Alexander V. Penson; Mark T. A. Donoghue; Walid Chatila; Joshua Armenia; Matthew T. Chang; Alison M. Schram; Philip Jonsson; Chaitanya Bandlamudi; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Understanding Long Tail D... (5R01CA204749-03), NIH | Targeting AKT-Mutant Huma... (1R01CA207244-01), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    Ploidy abnormalities are a hallmark of human cancers, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Andrea Ventura; Irtisha Singh; Joana A. Vidigal; Doron Betel; Ping Mu;
    Publisher: eScholarship, University of California
    Project: NIH | Investigating the functio... (5R01CA149707-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Investigating the tumor s... (1F31CA168356-01A1)

    Polycistronic microRNA (miRNA) clusters are a common feature of vertebrate genomes. The coordinated expression of miRNAs belonging to different seed families from a single transcriptional unit suggests functional cooperation, but this hypothesis has not been experimenta...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Divya Vinjamur; Laura Dassama; Falak Sher; davide seruggia; Mitchel Cole; Chunyan Ren; Claudio Macias Trevino; Takahiro Maeda; Vivien A. C. Schoonenberg;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Targeting the NuRD comple... (5R01DK111455-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Engineered Cas9 Nucleases... (5R01GM115911-03), NIH | Discovering disease-causa... (5R00HG008399-04), NIH | Next generation hybrid nu... (5R01AI117839-04), NIH | Epigenetic regulation of ... (4K08DK093705-05), NIH | A CENTER OF MOLECULAR HEM... (1U54DK110805-01), NIH | BIOLOGY OF HUMAN ERYTHROP... (5P01HL032262-24), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Pathophysiology of Human ... (5T32HL007574-23),...

    Developmental silencing of fetal globins serves as both a paradigm of spatiotemporal gene regulation and an opportunity for β-hemoglobinopathy therapeutic intervention. The NuRD chromatin complex participates in γ-globin repression. Here we use pooled CRISPR screening t...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Armenia, Joshua; Wankowicz, Stephanie A. M.; Liu, David; Gao, Jianjiong; Kundra, Ritika; Reznik, Ed; Chatila, Walid K.; Chakravarty, Debyani; Han, G. Celine; Coleman, Ilsa; ...
    Project: EC | SPICE (648670), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Resistance to Emerging An... (5K08CA188615-02), NIH | Clinical Development of T... (5P50CA097186-13), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, larger and uniform genomic analysis may identify additional recurrently mutated...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Qing V. Li; Gary Dixon; Nipun Verma; Bess P. Rosen; Miriam Gordillo; Renhe Luo; Chunlong Xu; Qiong Wang; Chew-Li Soh; Dapeng Yang; ...
    Project: NIH | Training Program in Devel... (5T32HD060600-04), NIH | Understanding Pancreatic ... (5R01DK096239-02), NIH | TRAINING PROGRAM IN MOLEC... (5T32GM008539-08), NIH | Systematic Identification... (1U01HG009380-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SVM-based Analysis of the... (5R01HG007348-05)

    Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highlighting the need for understanding developmental mechanisms. W...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Marcus Järås; Cem Meydan; Sagar Chhangawala; Ly Vu; Leandro Cerchietti; Javier Perales-Patón;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | ECOG Specimen Banking (3U24CA114737-05S1), NIH | ECOG-ACRIN INTEGRATED LEU... (5U10CA180827-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Uncovering the role for M... (5R01DK101989-03)

    Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and ...

8 research outcomes, page 1 of 1
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