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10 research outcomes, page 1 of 1
  • publication . Article . 2016
    Open Access
    Authors:
    Ingrid Yao Mattisson; Selvi Celik;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Androgen-deprivation therapy (ADT) for prostate cancer has been associated with increased risk for development of cardiovascular events and recent pooled analyses of randomized intervention trials suggest that this primarily is the case for patients with pre-existing ca...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Philipp Niethammer; Balázs Enyedi; Daniel Roxbury; Daniel A Heller; Prakrit Jena;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    The intrinsic near-infrared photoluminescence (fluorescence) of single-walled carbon nanotubes exhibits unique photostability, narrow bandwidth, penetration through biological media, environmental sensitivity, and both chromatic variety and range. Biomedical application...

  • publication . Article . 2017
    Open Access English
    Authors:
    W Graham;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    During amyloid fibril formation, amyloidogenic polypeptides misfold and self assemble into soluble pre-fibrillar aggregates, i.e., protofibrils, which elongate and mature into insoluble fibrillar aggregates. An emerging class of chaperones, chaperone-like amyloid bindin...

  • publication . Article . 2017
    Open Access
    Authors:
    michael ohliger;
    Publisher: eScholarship, University of California
    Project: NIH | Ascorbate-based biomarker... (1R01CA166766-01), NIH | Human Tissue Culture Bior... (5R00EB014328-03), NIH | Training Plan (1P41EB013598-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, now considered the most common liver disease in the western world. Approximately one-third of patients with NASH develop non-alchoholic steatohepatitis (NASH), histologically defined by lobular and po...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Thomas Reiner; Susanne Kossatz;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | Development of Nuclear Au... (5R21CA191679-02), NIH | Line-scanned MEMS-based d... (1R01DE023497-01)

    More sensitive and specific methods for early detection are imperative to improve survival rates in oral cancer. However, oral cancer detection is still largely based on visual examination and histopathology of biopsy material, offering no molecular selectivity or spati...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Joseph O. Deasy;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    The biological cause of clinically observed variability of normal tissue damage following radiotherapy is poorly understood. We hypothesized that machine/statistical learning methods using single nucleotide polymorphism (SNP)-based genome-wide association studies (GWAS)...

  • publication . Article . 2016
    Open Access
    Authors:
    Alexander Pietras; Bengt Westermark;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Evolutionary Dynamics of ... (4U54CA143798-03), NIH | P3IK Signaling and Biolog... (5U01CA141502-03), NIH | Role of the Perivascular ... (5U54CA163167-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability mediated by the ABC transporter ABCG2 using the side population assay, and their cha...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Raghu Kataru;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Head and Neck Training Pr... (5T32CA009685-23), NIH | SURGICAL ONCOLOGY RESEARC... (5T32CA009501-22), NIH | Mechanisms of fibrosis an... (4R01HL111130-05)

    Although recent studies have shown that obesity decreases lymphatic function, the cellular mechanisms regulating this response remain unknown. In the current study, we show that obesity results in perilymphatic accumulation of inflammatory cells and that local inhibitio...

  • publication . Article . 2016
    Open Access
    Authors:
    Kayvan Keshari;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Human Tissue Culture Bior... (5R00EB014328-03)

    Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting 13C nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice r...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Navid Paknejad;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Regulation of myelination... (1SC1NS000001-01), NIH | RESEARCH CENTER FOR STUDY... (2G12RR003037-16)

    The mechanical properties of living tissues have a significant impact on cell differentiation, but remain unexplored in the context of myelin formation and repair. In the PNS, the extracellular matrix (ECM) incorporates a basal lamina significantly denser than the loose...

10 research outcomes, page 1 of 1
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