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57 research outcomes, page 1 of 6
  • publication . Other literature type . Article . 2016 . Embargo End Date: 24 Aug 2016
    Open Access English
    Authors:
    Iratxe Macias; Leire Arreal; Charles Lawrie; roger gomis; Violeta Serra; Maria Vivanco; Marco Piva; Giacomo Domenici; Ana Rosa Cortazar; Patricia Zúñiga García; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCERMETAB (336343)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Article . 2016
    Open Access English
    Authors:
    Christopher Lengner; Benjamin Durham; Ly Vu;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Characterizing MSI2 in le... (1R01CA193842-01)

    Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expressi...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Kasthuri Kannan; Rachna Shah; Jie Yang; Erik Sulman;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | MOUSE GENETICS (2P30CA008748-43)

    Mutational inactivation of ATRX (α-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic consequences of ATRX deficiency remain unclear, as do tractable mechanisms for its therapeutic...

  • publication . Article . 2018
    Open Access
    Authors:
    Owen Dean;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Centrosome Regulation and... (5R01NS085004-04), NIH | Progenitor Regulation Und... (1R01NS105477-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Lineage-Dependent Assembl... (1R01MH101382-01A1), NIH | Molecular and Cellular Me... (4R01DA024681-09)

    Diverse GABAergic neurons arise from progenitors in the medial ganglionic eminence. Here, the authors show these progenitors are progressively fate-restricted, with early-born interneurons occupying cortex in an “inside-out” pattern and later-born types like chandelier ...

  • publication . Article . 2017
    Open Access English
    Authors:
    Zheng, Luqian; Mairhofer, Elisabeth; Teplova, Marianna; Zhang, Ye; Ma, Jinbiao; Patel, Dinshaw J.; Micura, Ronald; Ren, Aiming;
    Publisher: Nature Publishing Group
    Project: NIH | Biochemical and structura... (5U19CA179564-02), NIH | MOUSE GENETICS (2P30CA008748-43), FWF | Chemical synthesis of mod... (P 27947)

    Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions m...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Kim, Sarah H.; Da Cruz Paula, Arnaud; Basili, Thais; Dopeso, Higinio; Bi, Rui; Pareja, Fresia; da Silva, Edaise M.; Gularte-Mérida, Rodrigo; Sun, Zhen; Fujisawa, Sho; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs ...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Nadeem Riaz; Daniel Higginson; Pedro Blecua;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR ...

  • publication . Article . 2017
    Open Access
    Authors:
    Rajasekhar Vinagolu; Daniel A Heller; Samuel Brook;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    Alterations in PIK3CA, the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas. Inhibitors of PI3Kα show promising activity in various cancer types, but their use is curtailed by dose-limiting ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Hoelper, Dominik; Huang, Hongda; Jain, Aayushi Y.; Patel, Dinshaw J.; Lewis, Peter W.;
    Publisher: Springer Nature
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Dubin, Krista; Callahan, Margaret K.; Ren, Boyu; Khanin, Raya; Viale, Agnes; Ling, Lilan; No, Daniel; Gobourne, Asia; Littmann, Eric; Huttenhower, Curtis; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | TNF Mediated Immune Defen... (5R01AI042135-09)

    A subset of cancer patients treated with immune checkpoint blockade develops colitis. Here the authors show that lower abundance of Bacteroidetes and vitamin B biosynthetic modules in fecal samples of melanoma patients can predict their susceptibility to colitis followi...

57 research outcomes, page 1 of 6
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