Filters (3 )
Download Results
14 research outcomes, page 1 of 2
  • publication . Article . 2019
    Open Access English
    Authors:
    Hyejin Choi; Jiehui Deng; kwok kin wong;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Graphical Abstract

  • publication . Article . 2017
    Open Access English
    Authors:
    Cheng Zhang;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A network platform to con... (1R01CA196631-01A1), NIH | A new hypothesis: role of... (5R01AG043531-04), NIH | Hematopoietic potential o... (4R00HL093212-03)

    In Brief Zhang et al. demonstrate that GLUT3 suppresses somatic cell-specific oxidative phosphorylation in pluripotent stem cells. Low GLUT3 results in higher glutathione, blunting the DNA damage response, and citrate depletion, reducing histone acetylation. Expression ...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Tyler Hitchman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Administrative Core (5P50CA140146-04), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | An integrative approach t... (1DP2CA174499-01), NIH | Understanding the roles o... (1K08CA140946-01), NIH | Defining the Role of ERG ... (5R01CA193837-02), NIH | Elucidating the roles of ... (5K08CA151660-05)

    In Brief Moore et al. generate a preclinical mouse model of melanoma that recapitulates features of aggressive uveal melanoma. By comparing murine and human melanomas, they identify a dependency on RasGRP3 in uveal melanoma.

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Christos Hatzis; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | The landscape of long non... (PZ00P3_168165)

    SUMMARY Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the sa...

  • publication . Article . 2019
    Open Access English
    Authors:
    Amy Sun; Sergei B. Koralov;
    Publisher: Elsevier
    Project: NIH | Regulation of Nfil3 in in... (1R01AI130043-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | ELUCIDATION OF IMMUNOGLOB... (5R01AI072194-04), NIH | The natural killer cell r... (1R01AI100874-01), NIH | Delineating The Differenc... (1R21AI137752-01A1), NIH | RNA-directed targeting of... (5R01AI124186-02)

    In Brief Yen et al. demonstrate that CHD4, a component of the NuRD remodeling complex, is essential for early B cell development, represses p53 expression in mature B cells, and influences the recruitment of AID to DNA during class switch recombination.

  • publication . Article . 2020
    Open Access
    Authors:
    Pierre Billon; Tarun S. Nambiar; Samuel B. Hayward; Maria P. Zafra; Emma M. Schatoff; Koichi Oshima; Andrew Dunbar; Marco Breinig; Young C. Park; Han S. Ryu; ...
    Publisher: Elsevier BV
    Project: NIH | Molecular Mechanisms of I... (5P01CA174653-02), NIH | Transcriptional regulatio... (5R01GM117064-03), NIH | CANCER CENTER CORE SUPPOR... (3P30CA013696-21S1), NIH | Replication fork remodeli... (5R01CA197774-02), NIH | The BARD1 tumor suppresso... (5R01CA172272-03), NIH | Molecular characterizatio... (1R01CA216981-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular pathways and ta... (5R35CA210065-02)

    SUMMARY Genome editing technologies have transformed our ability to engineer desired genomic changes within living systems. However, detecting precise genomic modifications often requires sophisticated, expensive, and time-consuming experimental approaches. Here, we des...

  • publication . Article . 2016
    Open Access English
    Authors:
    John Petrini; Jane Skok; Gunnar Schotta;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | P95--LINKING DSB REPAIR A... (7R01GM059413-04)

    Graphical Abstract

  • publication . Article . 2019
    Open Access English
    Authors:
    James J. Asciolla; Marilyn D. Resh;
    Project: NIH | Fatty Acylation of Hedgeh... (3R01GM116860-01S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Graphical Abstract

  • publication . Article . 2017
    Open Access English
    Authors:
    Zhang, Juliet; Weinrich, Jarret A.P.; Russ, Jeffrey B.; Comer, John D.; Bommareddy, Praveen K.; DiCasoli, Richard J.; Wright, Christopher V.E.; Li, Yuqing; van Roessel, Peter J.; Kaltschmidt, Julia A.;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Molecular Mechanisms Regu... (5R01NS083998-03), NIH | CORE--MICROARRAY (1P30DK058404-01A1), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Diabetes Research and Tra... (5P60DK020593-25)

    SUMMARY Spinal interneurons are critical modulators of motor circuit function. In the dorsal spinal cord, a set of interneurons called GABApre presynaptically inhibits proprioceptive sensory afferent terminals, thus negatively regulating sensory-motor signaling. Althoug...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Cristina Guardia-Laguarta;
    Project: NIH | Mechanisms and Function o... (5R01CA166413-05), NIH | Role of MMP-9 in selectiv... (5R01NS072428-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of the ULK1 Complex ... (1R01GM113013-01), NIH | Non-cell Autonomous Role ... (1R21NS099862-01A1)

    In Brief PINK1 mutations cause Parkinson’s disease. PINK1 is cleaved into a shorter 52-kDa form at the mitochondrial membrane, but regulation of the turnover of cleaved PINK1 is unknown. Liu et al. show that polyubiquitination of cleaved PINK1 regulates its degradation ...

14 research outcomes, page 1 of 2
Last index information