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6 research outcomes, page 1 of 1
  • publication . Article . 2016
    Open Access English
    Authors:
    Bastian Zimmer; Lorenz Studer;
    Publisher: The Authors.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The derivation of pituita... (5R21CA176700-02)

    Graphical Abstract

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Sun Young Chung; Lorenz Studer;
    Publisher: Elsevier BV
    Project: NIH | PD iPS Cell Line Consorti... (3U24NS078338-01S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MENOPAUSAL CHANGES IN HYP... (5R01HL098351-03), NIH | The role of a-synuclein a... (5R01NS092823-04), NIH | Human embryonic stem cell... (5R01NS052671-04)

    Shim, Studer, and colleagues demonstrate that using a floor-plate-based differentiation strategy, Parkinson's disease (PD) patient iPSC-derived mDA neurons recapitulate several PD phenotypes, including pathogenic protein accumulation, cell-type-specific vulnerability, m...

  • publication . Article . 2015
    Open Access English
    Authors:
    Liu, Zhong; Skamagki, Maria; Kim, Kitai; Zhao, Rui;
    Publisher: The Authors. Published by Elsevier Inc.
    Project: NIH | Hematopoietic potential o... (5R00HL093212-04), NIH | Analytic and Preparative ... (5P30AR048311-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A new hypothesis: role of... (5R01AG043531-04), NIH | UAB Center for AIDS Resea... (5P30AI027767-20)

    Highlights • Reprogramming may be initiated and maintained solely by transcription factors • miRNA activity as a whole facilitates reprogramming • Canonical miRNAs may be dispensable for reprogramming

  • publication . Article . 2013
    Open Access
    Authors:
    D’Hulst, Charlotte; Parvanova, Irena; Tomoiaga, Delia; Sapar, Maria L.; Feinstein, Paul;
    Publisher: Elsevier BV
    Project: NIH | Regulation of Odorant Rec... (1SC1GM088114-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Highlights • Fast aneuploidy detection of mESCs using quantitative real-time PCR • Simultaneous processing of multiple cell lines • Highly sensitive: identifies low percentage of aneuploidy within an ESC clone • Method can detect loss or gain of any chromosomal region o...

  • publication . Article . 2019
    Open Access
    Authors:
    Luo, Maoguo; Bai, Jianbo; Liu, Bofeng; Yan, Peiqiang; Zuo, Feifei; Sun, Hongyao; Sun, Ye; Xu, Xuanhao; Song, Zhihong; Yang, Yang; ...
    Publisher: Elsevier BV
    Project: NIH | Transforming Growth Facto... (5R37CA034610-24), NIH | MOUSE GENETICS (2P30CA008748-43)

    Summary Cellular responses to transforming growth factor β (TGF-β) depend on cell context. Here, we explored how TGF-β/nodal signaling crosstalks with the epigenome to promote mesendodermal differentiation. We find that expression of a group of mesendodermal genes depen...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Siera Rosen; Franz-Josef Müller; Doron Betel; Chao Zhang; Karen G. Wong;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Summary Human pluripotent stem cells (PSCs) provide an unlimited cell source for cell therapies and disease modeling. Despite their enormous power, technical aspects have hampered reproducibility. Here, we describe a modification of PSC workflows that eliminates a major...

6 research outcomes, page 1 of 1
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