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26 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shuchi Agrawal Singh; Mads Lerdrup; Ana-Luisa R Gomes; Harmen JG van de Werken; Jens Vilstrup Johansen; Robin Andersson; Albin Sandelin; Kristian Helin; Klaus Hansen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    textabstractThe PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (P...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shi Chen; Rafal P Wiewiora; Fanwang Meng; Nicolas Babault; Anqi Ma; Wenyu Yu; Kun Qian; Hao Hu; Hua Zou; Junyi Wang; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , EC | ULTRA-DD (115766), NIH | Discovery of Selective In... (5R01GM122749-02), NIH | Profile substrates and in... (1R01GM096056-01), WT , NIH | Interrogating Functions o... (1R01GM120570-01)

    Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these approaches to illu...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Kern, David M; Oh, SeCheol; Hite, Richard K; Brohawn, Stephen G;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | New approaches to underst... (1DP2GM123496-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | National Resource for Aut... (7P41GM103310-14), NIH | Structural and mechanisti... (1F32GM128263-01A1)

    <jats:title>Abstract</jats:title><jats:p>Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric ass...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Livshits, Geulah; Alonso-Curbelo, Direna; Morris, John P; Koche, Richard; Saborowski, Michael; Wilkinson, John Erby; Lowe, Scott W;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | PROTEOLYTIC CONTROL OF ON... (2P01CA013106-31), NIH | Mechanisms of tumor suppr... (1F32CA177072-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    [u'The pancreas produces many different hormones, as well as several substances important for digestion. To perform these roles, the pancreas contains different types of cells; for example, acinar cells make digestive enzymes that help to break down food. But, like othe...

  • publication . Article . 2017
    Open Access English
    Authors:
    Elizabeth V Wasmuth; John C Zinder; Dimitrios Zattas; Mom Das; Christopher D Lima;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural and Biochemica... (5F31GM097910-02)

    Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase. Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease Rrp6 a...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Reznik, Ed; Miller, Martin; Şenbabaoğlu, Yasin; Riaz, Nadeem; Sarungbam, Judy; Tickoo, Satish K; Al-Ahmadie, Hikmat A; Lee, William; Seshan, Venkatraman E; Hakimi, A Ari; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Center for Translat... (5U24CA143840-04)

    Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project. We observe a tendency for some cancers, especia...

  • publication . Article . 2017
    Open Access English
    Authors:
    Alberto Roselló-Díez; Daniel Stephen; Alexandra L Joyner;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | A novel genetic approach ... (5R21HD083860-02), NIH | MOUSE GENETICS (2P30CA008748-43)

    eLife digest As bones grow, their size is carefully controlled and coordinated with the growth of the other organs in the body. The mechanisms that control organ size also help the body to recover from injury, and play a key role in controlling body size and proportions...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Srivarsha Rajshekar; Jun Yao; Paige K Arnold; Sara G Payne; Yinwen Zhang; Teresa V Bowman; Robert J Schmitz; John R Edwards; Mary Goll;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Heterochromatin in the de... (5R01GM110092-02)

    Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5mC is well-establishe...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Harihar Basnet; Lin Tian; Karuna Ganesh; Yun-Han Huang; Danilo G Macalinao; Edi Brogi; Lydia WS Finley; Joan Massagué;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Investigating L1CAM-depen... (1K08CA230213-01), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Mechanisms of Escape from... (5F30CA203238-03), NIH | Cancer Chemotherapy Train... (5T32CA009207-29)

    Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq)...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ed Reznik; Qingguo Wang;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Center for Translat... (5U24CA143840-04), NIH | Core_Training (2P41GM103504-06)

    The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expression of the nuclear genome (nuDNA). Previously we described mtDNA copy number depl...

26 research outcomes, page 1 of 3
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