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47 research outcomes, page 1 of 5
  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Alexander R. Judkins; Daniel Martinez; Lisa M. Sullivan; Joanna J. Phillips; Craig B. Thompson; Peter W. Lewis; Arie Perry; Dmitry Yarilin; Michelle Madden Felicella; Mariarita Santi; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of IDH Mutations in ... (1R01CA168802-01A1), NIH | Unraveling glutamine meta... (5K08CA181475-05)

    Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M muta...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Michail Schizas; Dilip Giri; Colin B. Begg; Venkatraman E. Seshan; Victor P. Andrade; Tari A. King; Audrey Mauguen; Irina Ostrovnaya; Russell Towers; Rita A. Sakr; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Background Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from wo...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Sarah M. Cheal; Neil H. Bander; Edward K. Fung; Joseph R. Osborne; Daniel E. Spratt; Sandhya Chalasani; Blesida Punzalan; Steven M. Larson; Wolfgang A. Weber; Darren R. Veach; ...
    Publisher: Springer Nature
    Project: NIH | Image Analysis and Biosta... (5P50CA086438-08), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Immuno-PET With Anti-PSMA... (1R21CA153177-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) ...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Peter C. Albertsen; Matthew Kent; Michael Goodman; David F. Penson; Behfar Ehdaie; Janet L. Stanford; Andrew J. Vickers; Antoinette M. Stroup; Ann S. Hamilton; Peter T. Scardino;
    Publisher: Springer Nature
    Project: NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067007-009), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067010-000), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | HealthyMe/MiSalud Smartph... (1R01LM013039-01), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067006-003), NIH | Race, Comorbidity &Long T... (1R01CA114524-01A2), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067005-003), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067000-004), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067009-007), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background Although life expectancy estimation is vital to decision making for localized prostate cancer, there are few, if any, valid and usable tools. Our goal was to create and validate a prediction model for other cause mortality in localized prostate cancer patient...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Patty Wai; Magali Lacroix-Triki; Catherine F. Cowell; Paul M Wilkerson; Rachael Natrajan; Laurent Arnould; Sylvia Giard; Silvio E. Bromberg; Larry Norton; Xavier Sastre-Garau; ...
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background HER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2 agents. In a subset of these cases, heterogeneous distribution of HER2 gene amplification can be fo...

  • publication . Article . 2010
    Open Access English
    Authors:
    Tatiana Omelchenko; Xiaojian Xu; Alan Hall;
    Publisher: Springer Nature
    Project: NIH | Rho GTPases and polarity ... (5R01GM081435-06), NIH | MOUSE GENETICS (2P30CA008748-43)

    <p>Abstract</p> <p>Background</p> <p>Germline mutations in <it>LKB1 </it>result in Peutz-Jeghers Syndrome characterized by intestinal hamartomas and increased incidence of epithelial cancers. <it>LKB1 </it>encodes a serine/threonine kinase that plays an important role i...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Daly Avendano; Daly Avendano; Pascal A. T. Baltzer; Katja Pinker; Katja Pinker; Doris Leithner; Danny F. Martinez; Paola Clauser; Panagiotis Kapetas; Sunitha B. Thakur; ...
    Publisher: BioMed Central
    Project: EC | MURAB (688188), NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCER SCAN (828978), EC | HYPMED (667211)

    <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Available data proving the value of DWI for breast cancer diagnosis is mainly for enhancing masses; DWI may be less sensitive and specific in non-mass enhancement (NME) lesions. The ...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Emily Vertosick; Andrew J. Vickers;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background Studies of endurance running have typically involved elite athletes, small sample sizes and measures that require special expertise or equipment. Methods We examined factors associated with race performance and explored methods for race time prediction using ...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Joseph A. O'Donoghue; Pat Zanzonico; Nancy Y. Lee; Chaitanya R. Divgi; Eva Burnazi; Jeannine A. Ruby; Tobias Leibold; Shangde Cai; Jose G. Guillem; John L. Humm; ...
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background: Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistributi...

  • publication . Article . 2015
    Open Access
    Authors:
    Joseph A. O'Donoghue; Steven M. Larson; Steven M. Larson; Eze A. Wills; Lawrence H. Schwartz; Neil H. Bander; Peter M. Smith-Jones; Howard I. Scher; Howard I. Scher; Mithat Gonen; ...
    Publisher: Springer Nature
    Project: NIH | Radioimmunotherapy for Pr... (5K23CA102544-03), NIH | CANCER CHEMOTHERAPY PROGR... (3P01CA005826-27S1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Background J591 is a monoclonal antibody that targets the external domain of the prostate-specific membrane antigen (PSMA). Besides prostate cancer cells, it also targets the neovasculature of non-prostate solid tumors. We provide an analysis of the antibody mass-dose d...

47 research outcomes, page 1 of 5