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8 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Audrey Mauguen;
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Background Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from wo...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Daly Avendano; Maria Adele Marino; Doris Leithner; Sunitha Thakur; Blanca Bernard-Davila; Danny F. Martinez; Thomas H. Helbich; Elizabeth A. Morris; Maxine S. Jochelson; Pascal A. T. Baltzer; ...
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | MURAB (688188), EC | HYPMED (667211), EC | CANCER SCAN (828978)

    Abstract Background Available data proving the value of DWI for breast cancer diagnosis is mainly for enhancing masses; DWI may be less sensitive and specific in non-mass enhancement (NME) lesions. The objective of this study was to assess the diagnostic accuracy of DWI...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Knight, Julia A; Blackmore, Kristina M; Fan, Jing; Malone, Kathleen E; John, Esther M; Lynch, Charles F; Vachon, Celine M; Bernstein, Leslie; Brooks, Jennifer D; Reiner, Anne S; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Mammographic Density and ... (5R01CA168339-03), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Abstract Background Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram timing, and change with treatment. Multiv...

  • publication . Article . 2019
    Open Access English
    Authors:
    Eva Tonsing-Carter; Kathleen Bowie;
    Publisher: BMC
    Project: NIH | Cancer Center Support Gra... (3P30CA014599-36S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Therapeutic approaches to... (1R01CA204999-01A1), NIH | Glucocorticoid receptor-m... (5R01CA089208-08), NIH | Investigate the role of T... (1R01CA196648-01A1)

    Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Brooks, Jennifer D; Comen, Elizabeth A; Reiner, Anne S; Orlow, Irene; Leong, Siok F; Liang, Xiaolin; Mellemkjær, Lene; Knight, Julia A; Lynch, Charles F; John, Esther M; ...
    Publisher: BMC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Abstract Background Tamoxifen treatment greatly reduces a woman’s risk of developing a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline genetic variation. CYP2D6 is a key enzyme i...

  • publication . Article . 2010
    Open Access English
    Authors:
    Kenneth Leslie; Sizhi P Gao; Marjan Berishaj; Katrina Podsypanina; Hao Ho; Lionel Ivashkiv; Jacqueline Bromberg;
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Role of Stat3 in Breast C... (5R01CA087637-03)

    Introduction Tyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine and paracrine interleukin (IL)-6 signaling is the principal mechanism by which Stat3 ...

  • publication . Article . 2016
    Open Access
    Authors:
    Lene Mellemkjaer; Patrick Concannon;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Genome-Wide Association S... (5R01CA129639-05), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | Interaction of Radiation,... (5R01CA097397-03)

    Background Treatment with tamoxifen or chemotherapy reduces the risk of contralateral breast cancer (CBC). However, it is uncertain how long the protection lasts and whether the protective effect is modified by patient, tumor, or treatment characteristics. Methods The p...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    MARIA ADELE MARINO; Katja PINKER-DOMENIG, MD, EBBI;
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | HYPMED (667211)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>To evaluate the diagnostic performance of radiomic signatures extracted from contrast-enhanced magnetic resonance imaging (CE-MRI) for the assessment of breast cancer receptor statu...

8 research outcomes, page 1 of 1
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