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7 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Darren R. Veach; Joseph Osborne; Daniel E. Spratt;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Immuno-PET With Anti-PSMA... (1R21CA153177-01A1), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Image Analysis and Biosta... (5P50CA086438-08), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) ...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Joseph A O'Donoghue; Sean Carlin;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background: Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistributi...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Stephen null; Thomas Reiner;
    Publisher: SpringerOpen
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Core--Pharmacology Facili... (5P30CA091842-05), NIH | IMAGING BIOMARKERS FOR RA... (5R01CA155365-04), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NSF | IGERT: Returning the Radi... (0965983)

    Background Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-processing; despite much rese...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Giuseppe Carlucci; Andreas Paulus; Thomas Reiner; Christian Brand;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (4TL1TR000459-10), NSF | IGERT: Returning the Radi... (0965983), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Background Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible with whole-body imaging techniques. The design of nov...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Jorge Carrasquillo; Joseph A O'Donoghue;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (~ 185 MBq, 10 mg). Seven of these patients undergo...

  • publication . Article . 2018
    Open Access English
    Authors:
    Naga Vara Kishore Pillarsetty; Thomas Reiner;
    Publisher: Springer Berlin Heidelberg
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    Background The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Outi Maria Keinänen; Naga Vara Kishore Pillarsetty; Delphine Vivier; Anu Airaksinen; Mirkka P Sarparanta;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MICROPLATE SCINTILLATION/... (1S10RR013039-01), AKA | Pretargeted radiopharmace... (298481), NIH | MOUSE GENETICS (2P30CA008748-43), AKA | New radiolabeled molecula... (278056)

    Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and s...

7 research outcomes, page 1 of 1
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