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37 research outcomes, page 1 of 4
  • publication . Preprint . 2018
    Open Access
    Authors:
    Chen, Shi; Wiewiora, Rafal P.; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC , NIH | Discovery of Selective In... (5R01GM122749-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ULTRA-DD (115766), WT , NIH | Targeting Lysine Methyltr... (5R01CA218600-02), NIH | Epigenetic Therapy and Pr... (5R01HD088626-02), NIH | Profile substrates and in... (1R01GM096056-01)

    <jats:title>Abstract</jats:title><jats:p>Elucidating conformational heterogeneity of proteins is essential for understanding protein functions and developing exogenous ligands for chemical perturbation. While structural biology methods can provide atomic details of stat...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shuchi Agrawal Singh; Mads Lerdrup; Ana-Luisa R Gomes; Harmen JG van de Werken; Jens Vilstrup Johansen; Robin Andersson; Albin Sandelin; Kristian Helin; Klaus Hansen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    textabstractThe PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (P...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shi Chen; Rafal P Wiewiora; Fanwang Meng; Nicolas Babault; Anqi Ma; Wenyu Yu; Kun Qian; Hao Hu; Hua Zou; Junyi Wang; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , EC | ULTRA-DD (115766), NIH | Discovery of Selective In... (5R01GM122749-02), NIH | Profile substrates and in... (1R01GM096056-01), WT , NIH | Interrogating Functions o... (1R01GM120570-01)

    Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these approaches to illu...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Busam, Klaus J; Shah, Kara N; Gerami, Pedram; Sitzman, Thomas; Jungbluth, Achim A; Kinsler, Veronica;
    Publisher: LIPPINCOTT WILLIAMS & WILKINS
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT | Functional characterisati... (104076)

    : The formation of a nodule within a congenital melanocytic nevus (CMN) raises concerns about possible melanoma. Most new nodular growths that develop during childhood, however, are benign proliferative nodules (PN); melanoma is very rare. The distinction of melanoma fr...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Bruno Vincenzi; Mike Trower; Ajay Duggal; Pamela Guglielmini; Peter Harris; David Jackson; Mario E Lacouture; Emiliangelo Ratti; Giuseppe Tonini; Andrew Wood; ...
    Publisher: BMJ Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    <jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the efficacy of orvepitant (10 or 30 mg given once daily, orally for 4 weeks), a neurokinin-1 receptor antagonist, compared with placebo in reducing the intensity of epidermal growth factor receptor inhibit...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Hisham Bazzi;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    Regulated mesoderm migration is necessary for the proper morphogenesis and organ formation during embryonic development. Cell migration and its dependence on the cytoskeleton and signaling machines have been studied extensively in cultured cells; in contrast, remarkably...

  • publication . Article . 2020
    Open Access
    Authors:
    Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva;
    Publisher: Royal Society of Chemistry (RSC)
    Project: EC | THE DISCOVERIES CTR (739572), WT , EC | FoReCaST (668983), NIH | MOUSE GENETICS (2P30CA008748-43)

    We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale ...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; Eckel-Passow, Jeanette E.; Armstrong, Georgina; Rice, Terri; Chen, Yanwen; Wiencke, John K.; McCoy, Lucie S.; Hansen, Helen M.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | International Case Contro... (1R01CA139020-01A1), NIH | Clinical and Translationa... (3UL1RR024131-03S3), WT , NIH | Genetic and Molecular Epi... (5R01CA052689-13), NIH | BRAIN TUMOR SPORT GRANT (5P50CA097257-12), NIH | Baylor College of Medicin... (3P30CA125123-09S3), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | Biomarkers of survival in... (5R01CA126831-04)

    <jats:title>Abstract</jats:title><jats:p>Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma gen...

37 research outcomes, page 1 of 4
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