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8 research outcomes, page 1 of 1
  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Helen Lindsay; Nathaniel Campbell; Christian Mosimann; Lorenz Studer;
    Publisher: The Company of Biologists
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Malignant melanoma studie... (5F31CA196305-02), EC | MOSIMANN ZEBRAFISH (631984), NIH | Investigating the Role of... (1F99CA212436-01), SNSF | Deciphering the control o... (PP00P3_139093), NIH | The role of melanocyte pr... (1K08AR055368-01A2), NIH | Evolutionary dynamics of ... (1DP2CA186572-01)

    Summary: Here, we developed Transgene Electroporation in Adult Zebrafish (TEAZ), a method that enables researchers to study cancer and metastasis by introducing DNA elements focally into somatic adult tissue.

  • publication . Preprint . 2020
    Open Access
    Authors:
    Baggiolini, Arianna; Callahan, Scott J.; Trieu, Tuan; Tagore, Mohita M.; Montal, Emily; Weiss, Joshua M.; Tischfield, Sam E.; Fan, Yujie; Campbell, Nathaniel R.; Saurat, Nathalie; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Malignant melanoma studie... (5F31CA196305-02), SNSF | The roles of aging in tum... (P400PB_180672), NIH | Dissecting the complexity... (1R01CA229215-01), NIH | Dissecting the Ecology of... (1F30CA220954-01A1), NIH | TRAINING PROGRAM IN MOLEC... (5T32GM008539-08), SNSF | Distinguishing the Ageing... (P2ZHP3_171967), NIH | The role of melanocyte pr... (1K08AR055368-01A2), NIH | Investigating the Role of... (1F30CA236442-01),...

    <jats:title>Abstract</jats:title><jats:p>Oncogenes are only transforming in certain cellular contexts, a phenomenon called oncogenic competence. The mechanisms regulating this competence remain poorly understood. Here, using a combination of a novel human pluripotent st...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Rachael Natrajan; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | The landscape of long non... (PZ00P3_168165)

    Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histol...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Mergim Gjonbalaj; James W. Keith; Mytrang Do; Tobias M. Hohl; Eric G. Pamer; Simone Becattini;
    Publisher: American Society for Microbiology
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | Effect of founder event o... (3100-049679), SNSF | Identification of commens... (P2EZP3_159083)

    <jats:title>ABSTRACT</jats:title> <jats:p>The complex bacterial populations that constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those encoding β-lactamase enzymes (BLA), which degrade commonly prescribed antibiotics such as ampici...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Ilaria Alborelli; BRUNA SCAGGIANTE; Nicola Aceto;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Client centred palliative... (425568), SNSF | Topology of intracellular... (3100-008748), SNSF | The genomic analysis of c... (310030_138513)

    Abstract Pre-symptomatic screening of genetic alterations might help identify subpopulations of individuals that could enter into early access prevention programs. Since liquid biopsy is minimally invasive it can be used for longitudinal studies in healthy volunteers to...

  • publication . Other literature type . Article . 2017 . Embargo End Date: 01 Jun 2017
    Open Access
    Authors:
    Kevin P O'Rourke; Evangelia Loizou; Geulah Livshits; Emma M Schatoff; Timour Baslan; Eusebio Manchado; Janelle Simon; Paul B Romesser; Benjamin Leach; Teng Han; ...
    Publisher: Nature Publishing Group
    Project: NIH | A scalable platform for t... (1R01CA195787-01), SNSF | GENETICS AND EPIGENETICS ... (P2BEP3_152100), NIH | Modeling metastatic color... (5F30CA200110-02), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Defining the genetic requ... (5K22CA181280-02), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Colorectal cancer (CRC) is a leading cause of death in the developed world, yet facile preclinical models that mimic the natural stages of CRC progression are lacking. Through the orthotopic engraftment of colon organoids we describe a broadly usable immunocompetent CRC...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Joanna Cyrta; Anke Augspach; Maria Rosaria de Filippo; Davide Prandi; Phillip Thienger; Matteo Benelli; Victoria Cooley; Rohan Bareja; David Wilkes; Sung-Suk Chae; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | SPICE (648670), NIH | Collaborative genomic alt... (1R01CA233650-01), NIH | Towards Understanding Pro... (5R01CA125612-04), SNSF | The landscape of long non... (PZ00P3_168165), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    <jats:title>Abstract</jats:title><jats:p>Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in ∼10% of these patients is through lineage plasticity,...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Christos Hatzis; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | The landscape of long non... (PZ00P3_168165)

    SUMMARY Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the sa...

8 research outcomes, page 1 of 1
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