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11 research outcomes, page 1 of 2
  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Johnson, Dominic; Crawford, Margaret; Cooper, Tim; Bouuaert, Corentin Claeys; Keeney, Scott; Llorente, Bertrand; Garcia, Valerie; Neale, Matthew J.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | DNA-REPAIR-CHROMATIN (311336), RCUK | Control and impact of mei... (BB/M010279/1), WT | Spatial regulation of mei... (200843)

    <jats:title>Summary</jats:title><jats:p>Genetic variation arises during meiosis via repair of DNA double-strand breaks (DSBs) created by the topoisomerase-like Spo11 protein. These DSBs are thought to always occur sparsely across the genome, with isolated DSBs generatin...

  • publication . Article . 2013
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Sara Olson; Veronica Setiawan; Jirong Long; Marta Crous-Bou; Amanda Spurdle; Alison Margaret Dunning; ...
    Publisher: Springer Berlin Heidelberg
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Epidemiology of... (1R01CA105212-01A1), NIH | CALIFORNIA TEACHERS STUDY (5R01CA077398-09), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | GENES AND THE ESTROGEN EF... (1R01CA091019-01A1), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOLECULAR EPIDEMIOLOGIC S... (1R01CA090899-01), NHMRC | Molecular Epidemiology of... (339435),...

    Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggestin...

  • publication . Article . 2017
    Open Access
    Authors:
    Gregory A. Ross; Hannah E. Bruce Macdonald; Christopher Cave-Ayland; Ana I. Cabedo Martinez; Jonathan W. Essex;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | CCP-BioSim: Biomolecular ... (EP/J010189/1), RCUK | A Doctoral Training Centr... (EP/G03690X/1), RCUK | EPSRC Centre for Doctoral... (EP/L015722/1)

    The ability of grand canonical Monte Carlo (GCMC) to create and annihilate molecules in a given region greatly aids the identification of water sites and water binding free energies in protein cavities. However, acceptance rates without the application of biased moves c...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Josh Fass; David A. Sivak; Gavin E. Crooks; Kyle A. Beauchamp; Benedict Leimkuhler; John D. Chodera;
    Project: NSERC , NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Data-Driven Coarse-Graini... (EP/P006175/1), NSF | D3SC: EAGER: Collaborativ... (1738979)

    <jats:title>Abstract</jats:title><jats:p>While Langevin integrators are popular in the study of equilibrium properties of complex systems, it is challenging to estimate the timestep-induced discretization error: the degree to which the sampled phase-space or configurati...

  • publication . Article . 2020
    Open Access English
    Authors:
    Kevin Litchfield; James L. Reading; Emilia L. Lim; Hang Xu; Po Liu; Maise Al-Bakir; Yien Ning Sophia Wong; Andrew Rowan; Samuel A. Funt; Taha Merghoub; ...
    Publisher: Nature Publishing Group UK
    Project: EC | PLOIDYNET (607722), WT , NIH | MOUSE GENETICS (2P30CA008748-43), EC | PROTEUS (835297), RCUK | Lethal renal cell carcino... (MR/P014712/1), EC | THESEUS (617844), EC | CHROMAVISION (665233)

    Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune re...

  • publication . Article . Preprint . Other literature type . 2017
    Open Access English
    Authors:
    Michael Shirts; David Mobley; John Chodera;
    Publisher: eScholarship, University of California
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NSF | CAREER: Computing accurat... (1352608), NSF | Establishment of a Cyber-... (0840513), RCUK | CCP-BioSim: Biomolecular ... (EP/J010588/1)

    <jats:title>Abstract</jats:title><jats:p>Solvation free energies can now be calculated precisely from molecular simulations, providing a valuable test of the energy functions underlying these simulations. Here, we briefly review “alchemical” approaches for calculating t...

  • publication . Article . 2017
    Open Access
    Authors:
    Martin Lepsik; Anežka Tichá; Petr Pachl; Darren Johnson; Stancho Stanchev;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Membrane protein structur... (MC_U105184322), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), EC | RHOMBOID SUBSTRATES (304154)

    Summary Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeuti...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Pau Castel; Pedram Razavi;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Unraveling resistance to ... (1R01CA190642-01A1), RCUK | Understanding signalling ... (MC_UU_12016/2)

    Castel et al. show that PDK1 activates SGK1 to phosphorylate and inhibit TSC2, contributing to maintenance of mTORC1 activity and resistance of PIK3CA-mutant cancer cells to PI3Kα inhibition. Targeting either PDK1 or SGK1 restores the sensitivity of these resistant canc...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    David Mazaud; Benjamin Kottler; Catarina Gonçalves-Pimentel; Sandra Proelss; Nadine Tüchler; Celine Deneubourg; Yoshihiro Yuasa; Celine Diebold; Heinz Jungbluth; Eric C. Lai; ...
    Publisher: Society for Neuroscience
    Project: RCUK | Molecular mechanisms of T... (MR/L010666/1), RCUK | Drosophila as a model to ... (NC/L000199/1), RCUK | Mechanisms of action init... (BB/N001230/1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    <p>The fruitfly Drosophila melanogaster has been extensively used as a genetic model for the maintenance of nervous system's functions. Glial cells are of utmost importance in regulating the neuronal functions in the adult organism and in the progression of neurological...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
11 research outcomes, page 1 of 2
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