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7 research outcomes, page 1 of 1
  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Marcel Hohl; Aditya Mojumdar; Sarem Hailemariam; Vitaly Kuryavyi; Fiorella Ghisays; Kyle Sorenson; Matthew Chang; Barry S. Taylor; Dinshaw J. Patel; Peter M. Burgers; ...
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ROLES AND REGULATION OF P... (1P01CA087497-01), NIH | Rad50: Roles in chromo. s... (5R01GM056888-20), NIH | Mechanisms of DNA replica... (5R35GM118129-03), NSERC , CIHR

    Author summary A complex network of functions is required for suppressing tumorigenesis. These include processes that regulate cell growth and differentiation, processes that repair damage to DNA and thereby prevent cancer promoting mutations and signaling pathways that...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Chen, Shi; Wiewiora, Rafal P.; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC , NIH | Discovery of Selective In... (5R01GM122749-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ULTRA-DD (115766), WT , NIH | Targeting Lysine Methyltr... (5R01CA218600-02), NIH | Epigenetic Therapy and Pr... (5R01HD088626-02), NIH | Profile substrates and in... (1R01GM096056-01)

    <jats:title>Abstract</jats:title><jats:p>Elucidating conformational heterogeneity of proteins is essential for understanding protein functions and developing exogenous ligands for chemical perturbation. While structural biology methods can provide atomic details of stat...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shi Chen; Rafal P Wiewiora; Fanwang Meng; Nicolas Babault; Anqi Ma; Wenyu Yu; Kun Qian; Hao Hu; Hua Zou; Junyi Wang; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , EC | ULTRA-DD (115766), NIH | Discovery of Selective In... (5R01GM122749-02), NIH | Profile substrates and in... (1R01GM096056-01), WT , NIH | Interrogating Functions o... (1R01GM120570-01)

    Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest to integrate these approaches to illu...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Fanning, Sean W.; Jeselsohn, Rinath; Dharmarajan, Venkatasubramanian; Mayne, Christopher G.; Karimi, Mostafa; Buchwalter, Gilles; Houtman, Rene; Toy, Weiyi; Fowler, Colin E.; Lainé, Muriel; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Therapeutic approaches to... (1R01CA204999-01A1), NIH | Chemical, structural and ... (1R01CA220284-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , NIH | Unraveling molecular and ... (5R35GM124952-02), CIHR , NSF | CCF: EAGER: Dimension Red... (1546278)

    <jats:title>Abstract</jats:title><jats:p>Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the <jats:italic>ESR1</jats:italic> (estrogen receptor alpha (ERα) gene ligand-binding domain (LBD) r...

  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Xiao-Chuan Cai; Tuo Zhang; Eui-jun Kim; Ming Jiang; Ke Wang; Junyi Wang; Shi Chen; Nawei Zhang; Hong Wu; Fengling Li; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NSERC , NIH | Protein Arginine Methylat... (1R01CA213293-01), EC | ULTRA-DD (115766), NIH | Statistical Evaluation an... (1R21CA214845-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), WT , NIH | Interrogating Functions o... (1R01GM120570-01), NIH | Protein Arginine Methylat... (1R01CA236356-01), NIH | Profile substrates and in... (1R01GM096056-01)

    CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with pro-drug properties....

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Josh Fass; David A. Sivak; Gavin E. Crooks; Kyle A. Beauchamp; Benedict Leimkuhler; John D. Chodera;
    Project: NSERC , NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Data-Driven Coarse-Graini... (EP/P006175/1), NSF | D3SC: EAGER: Collaborativ... (1738979)

    <jats:title>Abstract</jats:title><jats:p>While Langevin integrators are popular in the study of equilibrium properties of complex systems, it is challenging to estimate the timestep-induced discretization error: the degree to which the sampled phase-space or configurati...

7 research outcomes, page 1 of 1
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