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  • publication . Article . 2017
    Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.
    Open Access English
    Authors:
    Luqian Zheng; Dinshaw J. Patel; Aiming Ren; Aiming Ren; Jinbiao Ma; Ronald Micura; Ye Zhang; Elisabeth Mairhofer; Marianna Teplova;
    doi: 10.1038/s41467-017-01276-y
    pmc: PMC5660989
    pmid: 29081514
    Publisher: Nature Publishing Group UK
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemical and structura... (5U19CA179564-02)

    Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions m...

1 research outcomes, page 1 of 1