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3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Dinshaw J. Patel; Jennifer Gebetsberger; Aiming Ren; Aiming Ren; Michael Andreas Juen; Christoph Kreutz; Ronald Micura; Nikola Vušurović; Pu Gao;
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | Biochemical and structura... (5U19CA179564-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), FWF | Single-molecule FRET inve... (I 1040), FWF | Seeing the invisible &#x9... (P 28725), SNSF | Exploring the function an... (P2BEP3_162061), FWF | Resolving excited states ... (P 26550), NIH | MOUSE GENETICS (2P30CA008748-43)

    The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architect...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Shuguang Yuan; Dinshaw J. Patel; Dinshaw J. Patel; Ronald Micura; Elisabeth Mairhofer; Aiming Ren; Juncheng Wang; Luqian Zheng; Kaiyi Huang; Christoph Falschlunger;
    Publisher: Proceedings of the National Academy of Sciences
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemical and structura... (5U19CA179564-02), FWF | Understanding hatchet rib... (P 31691)

    Small self-cleaving ribozymes catalyze site-specific cleavage of their own phosphodiester backbone with implications for viral genome replication, pre-mRNA processing, and alternative splicing. We report on the 2.1-Å crystal structure of the hatchet ribozyme product, wh...

  • publication . Article . 2017
    Open Access English
    Authors:
    Luqian Zheng; Dinshaw J. Patel; Aiming Ren; Aiming Ren; Jinbiao Ma; Ronald Micura; Ye Zhang; Elisabeth Mairhofer; Marianna Teplova;
    Publisher: Nature Publishing Group UK
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemical and structura... (5U19CA179564-02)

    Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions m...

3 research outcomes, page 1 of 1