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7 research outcomes, page 1 of 1
  • publication . Article . 2017
    Open Access English
    Authors:
    Zheng, Luqian; Mairhofer, Elisabeth; Teplova, Marianna; Zhang, Ye; Ma, Jinbiao; Patel, Dinshaw J.; Micura, Ronald; Ren, Aiming;
    Publisher: Nature Publishing Group
    Project: NIH | Biochemical and structura... (5U19CA179564-02), NIH | MOUSE GENETICS (2P30CA008748-43), FWF | Chemical synthesis of mod... (P 27947)

    Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions m...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Luqian Zheng; Christoph Falschlunger; Kaiyi Huang; Elisabeth Mairhofer; Shuguang Yuan; Juncheng Wang; Dinshaw J. Patel; Ronald Micura; Aiming Ren;
    Publisher: National Academy of Sciences
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemical and structura... (5U19CA179564-02), FWF | Understanding hatchet rib... (P 31691), FWF | Chemical synthesis of mod... (P 27947)

    Small self-cleaving ribozymes catalyze site-specific cleavage of their own phosphodiester backbone with implications for viral genome replication, pre-mRNA processing, and alternative splicing. We report on the 2.1-Å crystal structure of the hatchet ribozyme product, wh...

  • publication . Other literature type . Article . 2020
    Open Access
    Authors:
    Teplova, Marianna; Falschlunger, Christoph; Krasheninina, Olga; Egger, Michaela; Ren, Aiming; Patel, Dinshaw J.; Micura, Ronald;
    Publisher: Wiley
    Project: FWF | Chemical synthesis of mod... (P 27947), FWF | Novel synthetic pathways ... (M 2517), NIH | MOUSE GENETICS (2P30CA008748-43), FWF | Understanding hatchet rib... (P 31691), NIH | Biochemical and structura... (5U19CA179564-02)

    Abstract Pistol ribozymes constitute a new class of small self‐cleaving RNAs. Crystal structures have been solved, providing three‐dimensional snapshots along the reaction coordinate of pistol phosphodiester cleavage, corresponding to the pre‐catalytic state, a vanadate...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Wolfgang Bogner; Katja PINKER-DOMENIG, MD, EBBI;
    Publisher: SpringerOpen
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | HYPMED (667211), FWF | Whole body image analysis... (I 2714)

    Background Multiparametric positron emission tomography/magnetic resonance imaging (mpPET/MRI) shows clinical potential for detection and classification of breast lesions. Yet, the contribution of features for computer-aided segmentation and diagnosis (CAD) need to be b...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Julia Batki; Jakob Schnabl; Juncheng Wang; Dominik Handler; Veselin I. Andreev; Christian E. Stieger; Maria Novatchkova; Lisa Lampersberger; Kotryna Kauneckaite; Wei Xie; ...
    Project: FWF | RNA Biology (W 1207), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), EC | PIWI-Chrom (682181)

    <jats:title>ABSTRACT</jats:title><jats:p>The PIWI-interacting RNA (piRNA) pathway protects animal genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent t...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Obenauf, Anna C; Zou, Yilong; Ji, Andrew L; Vanharanta, Sakari; Shu, Weiping; Shi, Hubing; Kong, Xiangju; Bosenberg, Marcus C; Wiesner, Thomas; Rosen, Neal; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), FWF | The impact of stochastic ... (J 3013)

    Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that promote tumour growth, dissemination and metastasis of drug-resistant cancer cell clones, and increase the survi...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Ren, Aiming; Vušurović, Nikola; Gebetsberger, Jennifer; Gao, Pu; Juen, Michael; Kreutz, Christoph; Micura, Ronald; Patel, Dinshaw J;
    Project: FWF | Resolving excited states ... (P 26550), NIH | NE-CAT Center for Advance... (4P41GM103403-14), FWF | Single-molecule FRET inve... (I 1040), SNSF | Exploring the function an... (P2BEP3_162061), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemical and structura... (5U19CA179564-02), FWF | Chemical synthesis of mod... (P 27947), FWF | Seeing the invisible &#x9... (P 28725)

    The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architect...

7 research outcomes, page 1 of 1
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