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29 research outcomes, page 1 of 3
  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Marcel Hohl; Aditya Mojumdar; Sarem Hailemariam; Vitaly Kuryavyi; Fiorella Ghisays; Kyle Sorenson; Matthew Chang; Barry S. Taylor; Dinshaw J. Patel; Peter M. Burgers; ...
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ROLES AND REGULATION OF P... (1P01CA087497-01), NIH | Rad50: Roles in chromo. s... (5R01GM056888-20), NIH | Mechanisms of DNA replica... (5R35GM118129-03), NSERC , CIHR

    Author summary A complex network of functions is required for suppressing tumorigenesis. These include processes that regulate cell growth and differentiation, processes that repair damage to DNA and thereby prevent cancer promoting mutations and signaling pathways that...

  • publication . Article . 2016
    Open Access English
    Authors:
    Michael Hoffmeister; Richard Hayes; Bette Caan; Fredrick Schumacher; Tabitha Harrison; Stephanie Bien; Sébastien KÜRY; Mark Jenkins; Hermann Brenner;
    Publisher: Public Library of Science
    Project: NIH | Cancer Prevention Trainin... (5R25CA094880-12), NIH | Hormones and Colon Cancer... (5R01CA076366-07), NIH | Ontario Registry for Stud... (3U01CA074783-09S2), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | AROMATIC AMINES AND COLON... (5R01CA060987-03), NIH | NUTRITIONAL AND BIOCHEMIC... (5R01CA042182-09), NIH | AUSTRALASIAN COLORECTAL C... (5U01CA097735-05),...

    Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Ibrahim El-Hamamy;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Mouse models to discover ... (5R01CA159859-07), NIH | Engrailed genes and cereb... (5R37MH085726-09), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Developmental studies to ... (5R01CA192176-02), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | Medulloblastoma and Metas... (5R01CA148699-02), CIHR

    <jats:title>Summary</jats:title><jats:p>The study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study &gt;6...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Thilo Dörk; Stuart MacGregor; Sara Olson; Anna Jakubowska; Liisa M Pelttari; Susan Ramus; Tomasz Kluz; Ian Campbell; Jolanta Lissowska; Yi Lu; ...
    Publisher: eScholarship, University of California
    Project: NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | Steroid Hormone Genes and... (5R01CA112523-03), NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Ovarian Cancer and Gonado... (5R03CA115195-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | MOUSE GENETICS (2P30CA008748-43),...

    BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potenti...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Shuji Ogino; Richard Hayes; Michael Hoffmeister; Fredrick Schumacher; Tabitha Harrison; Bette Caan; Mark Jenkins; Hermann Brenner;
    Publisher: The University of North Carolina at Chapel Hill University Libraries
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | Cancer Prevention Trainin... (5R25CA094880-12), NIH | GENETIC EPIDEMIOLOGIC STU... (5R01CA059045-04), NIH | Molecular pathological ep... (2U01CA137088-05), NIH | EPIDEMIOLOGIC STUDIES OF ... (5P01CA033619-05), WT , NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | Ontario Registry for Stud... (3U01CA074783-09S2), NIH | AUSTRALASIAN COLORECTAL C... (5U01CA097735-05),...

    BACKGROUND: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with ...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Fanning, Sean W.; Jeselsohn, Rinath; Dharmarajan, Venkatasubramanian; Mayne, Christopher G.; Karimi, Mostafa; Buchwalter, Gilles; Houtman, Rene; Toy, Weiyi; Fowler, Colin E.; Lainé, Muriel; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Therapeutic approaches to... (1R01CA204999-01A1), NIH | Chemical, structural and ... (1R01CA220284-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NSERC , NIH | Unraveling molecular and ... (5R35GM124952-02), CIHR , NSF | CCF: EAGER: Dimension Red... (1546278)

    <jats:title>Abstract</jats:title><jats:p>Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the <jats:italic>ESR1</jats:italic> (estrogen receptor alpha (ERα) gene ligand-binding domain (LBD) r...

  • publication . Article . 2017
    Open Access English
    Authors:
    Tsangaris, Elena; Riff, Karen W. Y. Wong; Goodacre, Tim; Forrest, Christopher R.; Dreise, Marieke; Sykes, Jonathan; de Chalain, Tristan; Harman, Karen; O'Mahony, Aisling; Pusic, Andrea L.; ...
    Publisher: Wolters Kluwer Health
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), CIHR

    Background: The CLEFT-Q is a new patient-reported outcome instrument designed to measure outcomes that matter to patients. The aim of this qualitative study was to establish content validity of the CLEFT-Q in patients who differ by age and culture. Methods: Patients age...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Matthew T. Sorbara; Krista Dubin; Eric R. Littmann; Thomas U. Moody; Emily Fontana; Ruth Seok; Ingrid M. Leiner; Ying Taur; Jonathan U. Peled; Marcel R.M. van den Brink; ...
    Publisher: Rockefeller University Press
    Project: NIH | Innate Immune Defense aga... (5R01AI095706-03), NIH | Systems Biology of Microb... (5U01AI124275-03), NIH | TNF Mediated Immune Defen... (5R01AI042135-09), NIH | MOUSE GENETICS (2P30CA008748-43), CIHR

    Klebsiella pneumoniae, Escherichia coli, and other members of the Enterobacteriaceae family are common human pathogens that have acquired broad antibiotic resistance, rendering infection by some strains virtually untreatable. Enterobacteriaceae are intestinal residents,...

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