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190 research outcomes, page 1 of 19
  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Marcel Hohl; Aditya Mojumdar; Sarem Hailemariam; Vitaly Kuryavyi; Fiorella Ghisays; Kyle Sorenson; Matthew Chang; Barry S. Taylor; Dinshaw J. Patel; Peter M. Burgers; ...
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ROLES AND REGULATION OF P... (1P01CA087497-01), NIH | Rad50: Roles in chromo. s... (5R01GM056888-20), NIH | Mechanisms of DNA replica... (5R35GM118129-03), NSERC , CIHR

    Author summary A complex network of functions is required for suppressing tumorigenesis. These include processes that regulate cell growth and differentiation, processes that repair damage to DNA and thereby prevent cancer promoting mutations and signaling pathways that...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Tan, Jiaxing; Jing, Longlong; Huo, Yumei; Tian, Yingli; Akin, Oguz;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Lung segmentation in computerized tomography (CT) images is an important procedure in various lung disease diagnosis. Most of the current lung segmentation approaches are performed through a series of procedures with manually empirical parameter adjustments in each step...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Arora, Arshi; Olshen, Adam B.; Seshan, Venkatraman E.; Shen, Ronglai;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>ABSTRACT</jats:title><jats:p>Molecular phenotypes of cancer are complex and influenced by a multitude of factors. Conventional unsupervised clustering of heterogeneous cancer patient populations is inevitably driven by the dominant variation from major facto...

  • publication . Preprint . Article . 2017
    Open Access
    Authors:
    Claeys Bouuaert, Corentin; Keeney, Scott;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Mlh1-Mlh3 (MutLγ) is a mismatch repair factor with a central role in formation of meiotic crossovers, presumably through resolution of double Holliday junctions. MutLγ has DNA-binding, nuclease, and ATPase activities, but how these relate to one another and to in vivo f...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Swenson, David W.H.; Prinz, Jan-Hendrik; Noe, Frank; Chodera, John D.; Bolhuis, Peter G.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ScaleCell (772230), EC | E-CAM (676531)

    <jats:p>Transition path sampling techniques allow molecular dynamics simulations of complex systems to focuson rare <jats:italic>dynamical events</jats:italic>, providing insight into mechanisms and the ability to calculate rates inaccessibleby ordinary dynamics simulat...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Chen, Shi; Wiewiora, Rafal P.; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC , NIH | Discovery of Selective In... (5R01GM122749-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ULTRA-DD (115766), WT , NIH | Targeting Lysine Methyltr... (5R01CA218600-02), NIH | Epigenetic Therapy and Pr... (5R01HD088626-02), NIH | Profile substrates and in... (1R01GM096056-01)

    <jats:title>Abstract</jats:title><jats:p>Elucidating conformational heterogeneity of proteins is essential for understanding protein functions and developing exogenous ligands for chemical perturbation. While structural biology methods can provide atomic details of stat...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Susanne Kossatz; Giacomo Pirovano; Paula Demétrio De Souza França; Arianna L. Strome; Sumsum P. Sunny; Daniella Karassawa Zanoni; Audrey Mauguen; Brandon Carney; Christian Brand; Veer Shah; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Rapid, quantitative and a... (1R43CA228815-01A1), NIH | Evaluation of PARP1 targe... (1K99CA218875-01A1), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    <jats:title>Abstract</jats:title><jats:p>Major determining factors for survival of patients with oral, oropharyngeal, and esophageal cancer are early detection, the quality of surgical margins, and the contemporaneous detection of residual tumor. Intuitively, the expose...

  • publication . Article . Preprint . Other literature type . 2017
    Open Access
    Authors:
    Jorge Gómez Tejeda Zañudo;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Mechanistic models of within-cell signal transduction networks can explain how these networks integrate internal and external inputs to give rise to the appropriate cellular response. ...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Ortiz, Michael V.; Ahmed, Saima; Burns, Melissa; Henssen, Anton G.; Hollmann, Travis J.; MacArthur, Ian; Gunasekera, Shehana; Gaewsky, Lyvia; Bradwin, Gary; Ryan, Jeremy; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structure and function of... (1R01CA214812-01A1), NIH | MSK Paul Calabresi Career... (5K12CA184746-02), NIH | Children's Oncology Group... (5U10CA180899-04)

    <jats:title>Abstract</jats:title><jats:p>Wilms tumor (WT) is the most common childhood kidney cancer. To improve risk stratification and identify novel therapeutic targets for patients with WT, we used high-resolution mass spectrometry proteomics to identify urine tumor...

  • publication . Preprint . 2018
    Open Access English
    Authors:
    Sol Shenker; Eric Lai;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | BEN factors are conserved... (5R01NS074037-02), NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>The recent beyond-exponential growth in diverse collections of deep sequencing datasets creates enormous opportunities for discovery, concomitant with new challenges for displaying and interpreting these data. Notably, the availa...

190 research outcomes, page 1 of 19
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