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473 research outcomes, page 1 of 48
  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Peter Lewis; Lisa Sullivan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Unraveling glutamine meta... (5K08CA181475-05), NIH | Role of IDH Mutations in ... (1R01CA168802-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M muta...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Melody Smith;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Stem cell transplantation (SCT), an effective therapy for amyloid light chain (AL) amyloidosis patients, is associated with low treatment-related mortality (TRM) with appropriate patient selection and risk-adapted dosing of melphalan (RA-SCT). Consolidation after SCT in...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Yaohua Xue; Luciano Martelotto; Timour Baslan; Alberto Vides; Martha Solomon; Trang Thi Mai; Neelam Chaudhary; Greg J Riely; Bob T Li; Kerry Scott; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Elucidating the regulatio... (5K08CA191082-02)

    The principles governing evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of BRAF amplification (BRAFamp) in patient-derived tumor xenografts (PDX) treated with a direct ERK inhibitor, alone or in combi...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Audrey Mauguen;
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Background Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from wo...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Andrea Ventura; Juan Camilo Correa; Doron Betel;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background MicroRNAs (miRNAs) are potential biomarkers in various malignancies. We aim to characterize miRNA expression in intrahepatic cholangiocarcinoma (ICC) and identify circulating plasma miRNAs with potential diagnostic and prognostic utility. Methods Using deep-s...

  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Marcel Hohl; Aditya Mojumdar; Sarem Hailemariam; Vitaly Kuryavyi; Fiorella Ghisays; Kyle Sorenson; Matthew Chang; Barry S. Taylor; Dinshaw J. Patel; Peter M. Burgers; ...
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ROLES AND REGULATION OF P... (1P01CA087497-01), NIH | Rad50: Roles in chromo. s... (5R01GM056888-20), NIH | Mechanisms of DNA replica... (5R35GM118129-03), NSERC , CIHR

    Author summary A complex network of functions is required for suppressing tumorigenesis. These include processes that regulate cell growth and differentiation, processes that repair damage to DNA and thereby prevent cancer promoting mutations and signaling pathways that...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    GIUSEPPE PETRALIA; David Collins; Giuseppe PETRALIA; STEFANO FANTI; Dow-Mu Koh;
    Publisher: European Association of Urology. Published by Elsevier B.V.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Context Comparative reviews of whole-body magnetic resonance imaging (WB-MRI) and positron emission tomography/computed tomography (CT; with different radiotracers) have shown that metastasis detection in advanced cancers is more accurate than with currently used CT and...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Darren R. Veach; Joseph Osborne; Daniel E. Spratt;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Immuno-PET With Anti-PSMA... (1R21CA153177-01A1), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Image Analysis and Biosta... (5P50CA086438-08), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) ...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Oakley Olson;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Macrophage ... (1F31CA171384-01)

    SUMMARY Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associat...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Chakraborty, Saptarshi; Arora, Arshi; Begg, Colin B.; Shen, Ronglai;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering ...

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