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744 research outcomes, page 1 of 75
  • publication . Article . 2017
    Open Access English
    Authors:
    Yingxia Liu; Ziad Saleh; Yulin Song; Maria Chan; Xiang Li; Chengyu Shi; Xin Qian; Xiaoli Tang;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Segmentation of prostate Cone Beam CT (CBCT) images is an essential step towards real-time adaptive radiotherapy (ART). It is challenging for Calypso patients, as more artifacts generated by the beacon transponders are present on the images. We herein propose a novel wa...

  • publication . Article . Other literature type . 1998
    Open Access English
    Authors:
    Alpha Yap;
    Publisher: The Rockefeller University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biochemistry and Regulati... (5R01GM052717-16)

    <jats:p>Cadherin cell–cell adhesion molecules form membrane-spanning molecular complexes that couple homophilic binding by the cadherin ectodomain to the actin cytoskeleton. A fundamental issue in cadherin biology is how this complex converts the weak intrinsic binding ...

  • publication . Article . 2017
    Open Access
    Authors:
    Olujide Arije;
    Publisher: American Society of Clinical Oncology (ASCO)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:sec><jats:title>Purpose</jats:title><jats:p> In low- and middle-income countries like Nigeria, women present with advanced breast cancer at an earlier age. Given the limited resources, development of screening programs that parallel resource capabilities of low- a...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Robert J. Motzer; Bernard Escudier; Thomas Powles; Christian Scheffold; Toni K. Choueiri;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background In the phase 3 METEOR trial (NCT01865747), cabozantinib significantly improved progression-free survival, overall survival, and objective response rate compared with everolimus in patients with advanced renal cell carcinoma (RCC) after prior antiangiogenic th...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Shan Tan; Clovis Tauber; Dimitris VISVIKIS; Vincent Jaouen;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Quantitative PET/CT Analy... (4R01CA172638-04)

    Abstract Introduction Automatic functional volume segmentation in PET images is a challenge that has been addressed using a large array of methods. A major limitation for the field has been the lack of a benchmark dataset that would allow direct comparison of the result...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Sanford Simon; David Requena;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | Cellular Pathogenesis of ... (5R56CA207929-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Intratumoral Heterogeneit... (5F31CA192835-03)

    <jats:p>A segmental deletion resulting in <jats:italic>DNAJB1–PRKACA</jats:italic> gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and youn...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access
    Authors:
    Elham Ahmadzadeh; N. Sumru Bayin; Xinli Qu; Aditi Singh; Linda Madisen; Daniel Stephen; Hongkui Zeng; Alexandra L. Joyner; Alberto Rosello-Diez;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Signaling pathways that r... (1R01NS092096-01), NIH | A novel genetic approach ... (5R21HD083860-02)

    <jats:title>Abstract</jats:title><jats:p>Thanks to many advances in genetic manipulation, mouse models have become very powerful in their ability to interrogate biological processes. In order to precisely target expression of a gene of interest to particular cell types,...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Kathryn Anderson; Anna-Katerina Hadjantonakis; Nadine Schrode;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic Analysis of Mouse... (5R01NS044385-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ISOLATION OF NOVEL MUTATI... (1R01HD035455-01A1)

    Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin2-GFP in centrosomes. Primary c...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Shen, Ronglai; Seshan, Venkatraman E.;
    Publisher: Oxford University Press (OUP)
    Project: NIH | Statistical Strategies fo... (5R01CA163251-03), NIH | Defining a novel subtype ... (1R21CA195365-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms and Modulators... (5P01CA129243-07)

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss...

  • publication . Article . 2015
    Open Access English
    Authors:
    Irene Orlow;
    Publisher: John Wiley & Sons, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Identification of Etiolog... (1R21CA167237-01A1), NIH | Statistical Strategies fo... (5R01CA163251-03)

    With the advent of increasingly detailed molecular portraits of tumor specimens, much attention has been directed toward identifying clinically distinct subtypes of cancer. Subtyping of tumors can also be accomplished with the goal of identifying distinct etiologies. We...

744 research outcomes, page 1 of 75
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