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839 research outcomes, page 1 of 84
  • publication . Article . 2014
    Open Access English
    Authors:
    Li-Xuan Qin; Qin Zhou;
    Publisher: Public Library of Science
    Project: NIH | Statistical Methods for N... (5R01CA151947-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    MicroRNA arrays possess a number of unique data features that challenge the assumption key to many normalization methods. We assessed the performance of existing normalization methods using two microRNA array datasets derived from the same set of tumor samples: one data...

  • publication . Article . 2018
    Open Access
    Authors:
    ming li;
    Publisher: Frontiers Media SA
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Ontogeny and Function of ... (5R01CA198280-02)

    Abstract Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non...

  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Murakami, Hajime; Lam, Isabel; Song, Jacquelyn; van Overbeek, Megan; Keeney, Scott;
    Publisher: bioRxiv
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Functional Characterizati... (5F31GM097861-02), NIH | Mechanism of meiotic reco... (5R01GM058673-15), NIH | Mechanism and regulation ... (5R35GM118092-03), NIH | The Role of Chromatin Arc... (5F32GM096692-02)

    <jats:p>To segregate accurately during meiosis, homologous chromosomes in most species must recombine. Very small chromosomes would risk missegregation if recombination were randomly distributed, so the double-strand breaks (DSBs) that initiate recombination are not hap...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Jaclyn Hechtman; Pedram Razavi; Maeve Lowery; Darren Feldman; Sumit Middha; Hyunjae (Ryan) Kim; Angelica Ochoa; Jonathan Coleman; Dalicia Reales; Bernard Bochner; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically-de...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Rose DiLoreto; Rohit Bose;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Understanding Resistance ... (4R01CA155169-05), NIH | Tri-Institutional Trainin... (5T32GM083937-05), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Role of the tumor microen... (1F99CA223063-01), NIH | Coordinate Regulation of ... (1R37CA215040-01A1), NIH | Investigating How a Balan... (1K08CA226348-01), NIH | Translational Research in... (5T32CA160001-03), NIH | Defining the Role of ERG ... (5R01CA193837-02), NIH | Genomic instability and D... (5K08CA187417-05)

    Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1–9. Here, by annotating the landscape of FOXA1 mutations from 3,086 huma...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Flynn, Simone; Hebert, Paul; Korenstein, Deborah; Ryan, Mark; Jordan, William B.; Keyhani, Salomeh;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Leveraging Social Media t... (1R18HS021946-01)

    Importance New dissemination methods are needed to engage physicians in evidence-based continuing medical education (CME). Objective To examine the effectiveness of social media in engaging physicians in non-industry-sponsored CME. Design We tested the effect of differe...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Audrey Mauguen; Venkatraman E. Seshan; Irina Ostrovnaya; Colin B. Begg;
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Statistical Methods for I... (5R01CA124504-02), NIH | Statistical Strategies fo... (5R01CA163251-03)

    Abstract Background We previously introduced a random-effects model to analyze a set of patients, each of which has two distinct tumors. The goal is to estimate the proportion of patients for which one of the tumors is a metastasis of the other, i.e. where the tumors ar...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Brenda Birmann; Giulio Genovese; Robert Handsaker;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NWO | Cluster computing in gene... (2300131050), NIH | Fast and accurate phasing... (5R21HG009513-02), NIH | Methods for Genome-wide A... (5R01HG006399-05), NIH | Joint Center for Mendelia... (5UM1HG008900-04), NIH | Clinical Diagnostic Seque... (1R01HD081256-01A1), NIH | Orchestra: A high perform... (1S10RR028832-01), NIH | Statistical methods for s... (5R01MH101244-02), NIH | Multi-allelic copy number... (5R01HG006855-02), NIH | Fast and powerful extensi... (1F32HG007805-01),...

    The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations, from 50 kb to 249 Mb long, that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using phase-b...

  • publication . Article . 2013
    Open Access
    Authors:
    D’Hulst, Charlotte; Parvanova, Irena; Tomoiaga, Delia; Sapar, Maria L.; Feinstein, Paul;
    Publisher: Elsevier BV
    Project: NIH | Regulation of Odorant Rec... (1SC1GM088114-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Highlights • Fast aneuploidy detection of mESCs using quantitative real-time PCR • Simultaneous processing of multiple cell lines • Highly sensitive: identifies low percentage of aneuploidy within an ESC clone • Method can detect loss or gain of any chromosomal region o...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Zheng, Qingfei; Osunsade, Adewola; David, Yael;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Application of intein-bas... (1R21DA044767-01A1)

    Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with general chromatin decompaction and...

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