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17 research outcomes, page 1 of 2
  • publication . Article . 2020
    Open Access English
    Authors:
    Charlie Saunders; christoffer johansen;
    Publisher: Umeå universitet, Institutionen för strålningsvetenskaper
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BRAIN TUMOR SPORT GRANT (5P50CA097257-12), NIH | Immune epigenetic biomark... (5R01CA207360-02)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian Randomisation (MR) framework to examine if lifestyle, cardiometabolic and inflammat...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Bruno Costa-Silva; Tang-Long Shen; Angela Di Giannatale; Sophia Ceder; Hector Peinado; Rajasekhar Vinagolu;
    Publisher: eScholarship, University of California
    Project: NIH | Characterization and Func... (1U01CA169538-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Exosome-mediated Transfer... (5R01CA169416-03)

    © 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour c...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    BARBARA MROCZKO; Piotr Lewczuk;
    Publisher: Springer Science and Business Media LLC
    Project: EC | EMIF (115372), NIH | MOUSE GENETICS (2P30CA008748-43)

    Background In this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the resulting aliquots and, consequently, the concentrati...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . 2017
    Open Access
    Authors:
    Shukla-Dave, Amita; Wassberg, Cecilia; Pucar, Darko; Schöder, Heiko; Goldman, Debra A; Mazaheri, Yousef; Reuter, Victor E; Eastham, James; Scardino, Peter T; Hricak, Hedvig;
    Publisher: Baishideng Publishing Group Inc.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IMAGING IN RISK ASSESSMEN... (5R01CA076423-05)

    AIM To assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging (1H-MRSI) and glycolysis as observed on 18F-fluorodeoxyglucose positron emission tomography/computed tom...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Wei Yang; Ken-Wing Lee; Raghvendra M. Srivastava; Fengshen Kuo; Chirag Krishna; Diego Chowell; Vladimir Makarov; Douglas Hoen; Martin G. Dalin; Leonard Wexler; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Identifying and targeting... (1R01DE027738-01), NIH | Elucidating genetics of r... (1R01CA205426-01A1), NIH | Functionalizing recurrent... (1K08DE024774-01), NIH | Towards Precision Immuno-... (1R35CA232097-01)

    Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens tha...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; Eckel-Passow, Jeanette E.; Armstrong, Georgina; Rice, Terri; Chen, Yanwen; Wiencke, John K.; McCoy, Lucie S.; Hansen, Helen M.; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BRAIN TUMOR SPORT GRANT (5P50CA097257-12), NIH | Genetic and Molecular Epi... (5R01CA052689-13), NIH | Clinical and Translationa... (3UL1RR024131-03S3), NIH | Baylor College of Medicin... (3P30CA125123-09S3), WT , NIH | International Case Contro... (1R01CA139020-01A1), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | Biomarkers of survival in... (5R01CA126831-04)

    <p>Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) ha...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . 2017
    Open Access English
    Authors:
    Joseph O. Deasy; Per Munck af Rosenschold;
    Publisher: Elsevier
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Purpose Prostate motion during radiation therapy (ie, intrafraction motion) can cause unwanted loss of radiation dose to the prostate and increased dose to the surrounding organs at risk. A compact but general statistical description of this motion could be use...

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