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6 research outcomes, page 1 of 1
  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access
    Lu null; Jaclyn Hechtman;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Here, we describe the dramatic response of a patient with an ETV6-NTRK3-driven mammary analogue secretory carcinoma to treatment with a pan-Trk inhibitor, and the development of acquired resistance linked to a novel NTRK3 mutation that interferes with drug binding. This...

  • publication . Article . 2019
    Open Access
    Ghasemiesfe, Mehrnaz; Barrow, Brooke; Leonard, Samuel; Keyhani, Salomeh; Korenstein, Deborah;
    Publisher: American Medical Association (AMA)
    Project: NIH | Impact of marijuana on ad... (1R01HL130484-01A1), NIH | MOUSE GENETICS (2P30CA008748-43)

    Importance Marijuana use is common and growing in the United States amid a trend toward legalization. Exposure to tobacco smoke is a well-described preventable cause of many cancers; the association of marijuana use with the development of cancer is not clear. Objective...

  • publication . Other literature type . Article . 2018
    Open Access
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

  • publication . Preprint . 2020
    Open Access English
    Bryan C Szeglin; Chao Wu; Michael R Marco; Hyun Sung Park; Zeda Zhang; Bing Zhang; Julio Garcia-Aguilar; R Daniel Beauchamp; Xi Chen; J Joshua Smith;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | EMT regulation in gastroi... (2R01CA069457-16A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Molecular Imaging & T... (5P50CA095103-14), NIH | Organ Preservation in Rec... (5R01CA182551-04), NIH | Integrative prediction mo... (1R01CA158472-01A1)

    <jats:p>Objective: Loss of SMAD4 is associated with worse outcomes for colorectal cancer patients. We used gene ontology and bioinformatics to identify an RNA-based SMAD4-modulated profile and test its association with patient outcome. Design: Using a discovery dataset ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

6 research outcomes, page 1 of 1
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