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34 research outcomes, page 1 of 4
  • publication . Article . 2017
    Open Access English
    Authors:
    Julius C. Fischer; Michael Bscheider; Gabriel Eisenkolb; Chia-Ching Lin; Alexander Wintges; Vera Otten; Caroline A. Lindemans; Simon Heidegger; Martina Rudelius; Sébastien Monette; ...
    Project: NIH | Strategies to enhance imm... (5R01HL069929-12), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14), NIH | IL-22 in Thymic Regenerat... (5R01AI101406-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Strategies to Enhance Lym... (5R01AI080455-02), EC | CBM-INNATE (322865), NIH | Mucosal Immunity and Micr... (9R01AI100288-06A1)

    The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking m...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Kubik-Huch, Rahel A.; Vilgrain, Valérie; Krestin, Gabriel P.; Reiser, Maximilian F.; Attenberger, Ulrike I.; Muellner, Ada U.; Hess, Christopher P.; Hricak, Hedvig;
    Publisher: Springer Berlin Heidelberg
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Women in Focus: Be Inspired was a unique programme held at the 2019 European Congress of Radiology that was structured to address a range of topics related to gender and healthcare, including leadership, mentoring and the generational progression of women in medicine. I...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Andrew J Vickers; Ben Van Calster; Ewout W Steyerberg;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Dynamic, multi-cohort pre... (5R01CA179115-02), EC | CENTER-TBI (602150), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    © BMJ Publishing Group Ltd 2016. Many decisions in medicine involve trade-offs, such as between diagnosing patients with disease versus unnecessary additional testing for those who are healthy. Net benefit is an increasingly reported decision analytic measure that puts ...

  • publication . Article . 2016
    Open Access
    Authors:
    Permuth, J. B.; Reid, B.; Earp, M.; Chen, Y. A.; Monteiro, A. N. A.; Chen, Z.; Chenevix-Trench, G.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; ...
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05),...

    RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypo...

  • publication . Article . 2020
    Open Access English
    Authors:
    Thomas Reiner; Susanne Kossatz; Giacomo Pirovano; Carlos Pérez-Medina;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET nanoreporter image-gu... (1R01CA220234-01A1), NIH | Development of a Novel Pe... (5F32EB025050-02), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means ...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Nitya Ramkumar; Wijnholds, J;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    During gastrulation of the mouse embryo, individual cells ingress in an apparently stochastic pattern during the epithelial-to-mesenchymal transition (EMT). Here we define a critical role of the apical protein Crumbs2 (CRB2) in the gastrulation EMT. Static and live imag...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Brenda Birmann; Giulio Genovese; Robert Handsaker;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NWO | Cluster computing in gene... (2300131050), NIH | Fast and accurate phasing... (5R21HG009513-02), NIH | Methods for Genome-wide A... (5R01HG006399-05), NIH | Joint Center for Mendelia... (5UM1HG008900-04), NIH | Clinical Diagnostic Seque... (1R01HD081256-01A1), NIH | Orchestra: A high perform... (1S10RR028832-01), NIH | Statistical methods for s... (5R01MH101244-02), NIH | Multi-allelic copy number... (5R01HG006855-02), NIH | Fast and powerful extensi... (1F32HG007805-01),...

    The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations, from 50 kb to 249 Mb long, that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using phase-b...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Alice Lee; Penelope Webb; Allan Jensen; Signe Marie Jensen; Estrid Høgdall; Susan Ramus; Stacey Winham; Usha Menon; Lambertus Kiemeney;
    Publisher: Elsevier BV
    Project: NIH | Training Grant in Genomic... (5T32ES013678-05), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | CASE CONTROL STUDY OF OVA... (5R01CA074850-05), NIH | NORTHERN CALIFORNIA COOPE... (5U01CA069417-02), NIH | DNA POLYMORPHISMS IN OVAR... (5R01CA080742-04),...

    PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies h...

  • publication . Article . 2018
    Open Access English
    Authors:
    Roberts, Sheryl; Andreou, Chrysafis; Choi, Crystal; Donabedian, Patrick; Jayaraman, Madhumitha; Pratt, Edwin C.; Tang, Jun; Pérez-Medina, Carlos; Jason de la Cruz, M.; Mulder, Willem J. M.; ...
    Publisher: Royal Society of Chemistry
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Development of Nuclear Au... (5R21CA191679-02), NIH | Exploring PSMA Biology in... (1R01CA212379-01A1), NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | MRI-Photoacoustic-Raman N... (1R01EB017748-01A1), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    Optoacoustic imaging offers the promise of high spatial resolution and, at the same time, penetration depths well beyond the conventional optical imaging technologies, advantages that would be favorable for a variety of clinical applications. However, similar to optical...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ajay Gopal; Martin Hutchings; Ranjana Advani; PIER LUIGI ZINZANI;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biostatistics and Bioinfo... (2P50CA097274-06)

    International audience; In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in earl...

34 research outcomes, page 1 of 4
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