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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Niccola Funel; Stefano Landi; Federico Canzian; Amethyst Saldia; William Bamlet; Sean Cleary; Rachel Neale; Gabriele Capurso; Sara Olson; Oliver Strobel; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Planning, timing and quit... (1009767), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | Molecular Epidemiology of... (5R01CA109767-04), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NHMRC | Cancer Aetiology and Prev... (1060183), NHMRC | Case-Control Study of Gen... (442302), NIH | Case-Control Study of Pan... (5R01CA098870-03), NIH | CORE--COLORECTAL AND PANC... (5P50CA062924-05), NIH | Mayo Clinic SPORE in Panc... (5P50CA102701-02),...

    Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated...

  • publication . Preprint . Other literature type . 2017
    Open Access
    Authors:
    Azizi, Elham; Carr, Ambrose J.; Plitas, George; Cornish, Andrew E.; Konopacki, Catherine; Prabhakaran, Sandhya; Nainys, Juozas; Wu, Kenmin; Kiseliovas, Vaidotas; Setty, Manu; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Integrative Cancer Genomi... (5R01CA164729-03), NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | Single cell mapping of de... (7DP1HD084071-04)

    <jats:title>SUMMARY</jats:title><jats:p>Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We created an immune map of breast cancer using single-cell RNA-seq data...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

6 research outcomes, page 1 of 1
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