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70 research outcomes, page 1 of 7
  • publication . Other literature type . Article . 2016 . Embargo End Date: 24 Aug 2016
    Open Access English
    Authors:
    Iratxe Macias; Leire Arreal; Charles Lawrie; roger gomis; Violeta Serra; Maria Vivanco; Marco Piva; Giacomo Domenici; Ana Rosa Cortazar; Patricia Zúñiga García; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCERMETAB (336343)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Pau Castel; Pedram Razavi;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Unraveling resistance to ... (1R01CA190642-01A1), RCUK | Understanding signalling ... (MC_UU_12016/2)

    Castel et al. show that PDK1 activates SGK1 to phosphorylate and inhibit TSC2, contributing to maintenance of mTORC1 activity and resistance of PIK3CA-mutant cancer cells to PI3Kα inhibition. Targeting either PDK1 or SGK1 restores the sensitivity of these resistant canc...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    David Mazaud; Benjamin Kottler; Catarina Gonçalves-Pimentel; Sandra Proelss; Nadine Tüchler; Celine Deneubourg; Yoshihiro Yuasa; Celine Diebold; Heinz Jungbluth; Eric C. Lai; ...
    Publisher: Society for Neuroscience
    Project: RCUK | Molecular mechanisms of T... (MR/L010666/1), RCUK | Drosophila as a model to ... (NC/L000199/1), RCUK | Mechanisms of action init... (BB/N001230/1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    <p>The fruitfly Drosophila melanogaster has been extensively used as a genetic model for the maintenance of nervous system's functions. Glial cells are of utmost importance in regulating the neuronal functions in the adult organism and in the progression of neurological...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
  • publication . Thesis . 2005
    Open Access English
    Authors:
    Petrakis, T. G.;
    Publisher: University of London
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Yeast Elongator was initially isolated based on its interaction with the hyper-phosphorylated form of RNA polymerase II. Later on, it was shown to possesion intrinsic histone acetyl-transferase activity and to crosslink to nascent RNA in vivo. The six ELP genes were als...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Andreas Prlic; Gustavo Glusman; Michael A Hicks; Peter Rose; Jianjiong Gao;
    Publisher: eScholarship, University of California
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biomedical Data Translato... (3OT3TR002026-01S2)

    The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may ...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Masanori Okaniwa; ZHAN YAO;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Orexin/Hypocretin Recepto... (7P50AA017072-07)

    Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance. Inhibitors of...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Srivarsha Rajshekar; Jun Yao; Paige K Arnold; Sara G Payne; Yinwen Zhang; Teresa V Bowman; Robert J Schmitz; John R Edwards; Mary Goll;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Heterochromatin in the de... (5R01GM110092-02)

    Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5mC is well-establishe...

  • publication . Article . 2018
    Open Access English
    Authors:
    Dixon-Suen, Suzanne C.; Nagle, Christina M.; Thrift, Aaron P.; Pharoah, Paul D. P.; Ewing, Ailith; Pearce, Celeste Leigh; Zheng, Wei; Chenevix-Trench, Georgia; Fasching, Peter A.; Beckmann, Matthias W.; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | USC CANCER CENTER EPIDEMI... (2P01CA017054-17), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Ovarian Cancer and Gonado... (5R03CA115195-02), NIH | ROSWELL PARK MEMORIAL INS... (5P30CA016056-17), NIH | Phytoestrogens, alcohol, ... (1K07CA095666-01A1), NIH | PRE SURGICAL O6 BENZYLGUA... (3M01RR000056-38S3), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN067010-000), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Generating the evidence t... (1073898), EC | COGS (223175),...

    Background:\ud \ud Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.\ud M...

  • publication . Article . Other literature type . 2016
    Open Access Russian
    Authors:
    Ke Xu; Elliott Brea;
    Project: NIH | The Roles of Microglia an... (1F31CA167863-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Novel Nano-Constructs to ... (1R21CA128406-01), NIH | Improving therapy of glio... (5R01CA166078-04), NIH | MONOCLONAL ANTIBODY THERA... (5P01CA033049-13), NIH | Biology of Alpha Particle... (2R01CA055349-16A2), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cel...

70 research outcomes, page 1 of 7
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