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21 research outcomes, page 1 of 3
  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Mehmet E. Karasu; Nora Bouftas; Scott Keeney; Katja Wassmann;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:p>As obligate kinase partners, cyclins control the switch-like cell cycle transitions that orchestrate orderly duplication and segregation of genomes. Meiosis, the cell division that generates gametes for sexual reproduction, poses unique challenges because two ro...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Francesco Maura; Niccoló Bolli; Nicos Angelopoulos; Kevin J. Dawson; Daniel Leongamornlert; Inigo Martincorena; Thomas J. Mitchell; Anthony Fullam; Santiago Gonzalez; Raphael Szalat; ...
    Publisher: HAL CCSD
    Project: NIH | MOLECULAR MANIPULATION TO... (5I01BX001584-04), NIH | MOUSE GENETICS (2P30CA008748-43), EC | bECOMiNG (817997), NIH | Career Development Progra... (5P50CA100707-13)

    The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datase...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Rachael Natrajan; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Nature Publishing Group UK
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | The landscape of long non... (PZ00P3_168165)

    Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histol...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Edwige B. Garcin; Stéphanie Gon; Meghan R. Sullivan; Gregory J. Brunette; Anne De Cian; Jean-Paul Concordet; Carine Giovannangeli; Wilhelm G. Dirks; Sonja Eberth; Kara A. Bernstein; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The interplay between RAD... (5F31ES027321-02), NIH | Fluorescence microscopy f... (3R35GM118175-01S1), NIH | Deciphering the epistatic... (5F32GM110978-02), NIH | HOMOLOGY-DIRECTED DNA REP... (5R01CA185660-04)

    Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF1...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Florent Malard; Jakob R Passweg;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MARROW TRANSPLANTATION IN... (5P01CA023766-14)

    Background Graft-versus-host disease (GVHD) is one of the leading causes of non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods We evaluated the outcomes of two well-established strategies used for GVHD preven...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Mandelker, D; Donoghue, M; Talukdar, S; Bandlamudi, C; Srinivasan, P; Vivek, M; Jezdic, S; Hanson, H; Snape, K; Kulkarni, A; ...
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer susceptibility genes identified on tumour-only sequencing, it is often unclear whether they are of somatic or const...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Sebastian Müller; Loew Damarys; Kevin Sullivan; Lisa Prendergast; Genevieve Almouzni;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | EPIGENESYS (257082), SFI | Assembly of centromeric c... (05/RP1/B793), SFI | Structure and assembly of... (12/IA/1370), EC | MODHEP (259743)

    International audience; The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W is not inherited at ce...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ajay Gopal; Martin Hutchings; Ranjana Advani; PIER LUIGI ZINZANI;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biostatistics and Bioinfo... (2P50CA097274-06)

    International audience; In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in earl...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Bick, Ulrich; Trimboli, Rubina M; Athanasiou, Alexandra; Balleyguier, Corinne; Baltzer, Pascal AT; Bernathova, Maria; Borbély, Krisztina; Brkljacic, Boris; Carbonaro, Luca A; Clauser, Paola; ...
    Publisher: Springer Berlin Heidelberg
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), NIH | MOUSE GENETICS (2P30CA008748-43), EC | HYPMED (667211), EC | CANCER SCAN (828978)

    We summarise here the information to be provided to women and referring physicians about percutaneous breast biopsy and lesion localisation under imaging guidance. After explaining why a preoperative diagnosis with a percutaneous biopsy is preferred to surgical biopsy, ...

  • publication . Other literature type . Article . 2018 . Embargo End Date: 09 Jan 2019
    Open Access
    Authors:
    Cline, Melissa S; Liao, Rachel G; Parsons, Michael T; Paten, Benedict; Alquaddoomi, Faisal; Antoniou, Antonis; Baxter, Samantha; Brody, Larry; Cook-Deegan, Robert; Coffin, Amy; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Building the Medical Info... (5R01HG008918-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | EMERGE III CENTRAL SEQUEN... (5U01HG008676-02), NIH | Visualization hub for gen... (5U24CA210974-02), NIH | Cloud Based Resource for ... (5U24CA180951-05), NIH | The Future of PharmGKB Fu... (3U41HG009649-01S1), NHMRC | Research Fellowship – Gen... (1061779), NIH | Global Infrastructure for... (5U24CA210999-03), CIHR , NIH | Center for Big Data in Tr... (3U54HG007990-03S3),...

    The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understandi...

21 research outcomes, page 1 of 3
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