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18 research outcomes, page 1 of 2
  • publication . Preprint . 2018
    Open Access
    Authors:
    Swenson, David W.H.; Prinz, Jan-Hendrik; Noe, Frank; Chodera, John D.; Bolhuis, Peter G.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ScaleCell (772230), EC | E-CAM (676531)

    <jats:p>Transition path sampling techniques allow molecular dynamics simulations of complex systems to focuson rare <jats:italic>dynamical events</jats:italic>, providing insight into mechanisms and the ability to calculate rates inaccessibleby ordinary dynamics simulat...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    marco zappa; Arnauld VILLERS; Anssi Auvinen;
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Modeling prostate cancer ... (5U01CA157224-03), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Prospective validation of... (5R01CA160816-02)

    BACKGROUND: Prostate-specific antigen (PSA) screening and concomitant treatment can be implemented in several ways. The authors investigated how the net benefit of PSA screening varies between common practice versus “good practice.”. METHODS: Microsimulation screening a...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Xiaoyi Li; Yuri Pritykin; Carla P. Concepcion; Yuheng Lu; Gaspare La Rocca; Minsi Zhang; Peter J. Cook; Yu Wah Au; Olesja Popow; Joao A. Paulo; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Investigating the functio... (5R01CA149707-05), NIH | Investigating the tumor s... (1F31CA168356-01A1)

    <jats:title>SUMMARY</jats:title><jats:p>The identification of miRNA targets by Ago2 crosslinking-immunoprecipitation (CLIP) methods has provided major insights into the biology of this important class of non-coding RNAs. However, these methods are technically challengin...

  • publication . Article . 2016
    Open Access
    Authors:
    Vriend, Lianne E. M.; Prakash, Rohit; Chen, Chun-Chin; Vanoli, Fabio; Cavallo, Francesca; Zhang, Yu; Jasin, Maria; Krawczyk, Przemek M.;
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Double-strand break repai... (5R01GM054668-08)

    Abstract DNA double-strand breaks (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks (nicks) have also been shown to trigger HR. Both DSB- and nick-induced HR (nickHR) are exploited in advanced genome-engineering approach...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
  • publication . Preprint . 2020
    Open Access
    Authors:
    Ngo, Bryan; Kim, Eugenie; Osorio-Vasquez, Victoria; Doll, Sophia; Bustraan, Sophia; Luengo, Alba; Davidson, Shawn M.; Ali, Ahmed; Ferraro, Gino D.; Kang, Diane; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Understanding the role of... (5R21CA198028-02), NIH | Core--Bioengineering (1P01CA080124-01A1), NIH | Transport of Large Molecu... (5R01CA098706-08), NIH | Characterizing the role o... (5K22CA175228-02), NIH | The role of chromosomal i... (1DP5OD026395-01), NIH | Experimental Pathology (5P30CA016087-32), NIH | Regulation of glucose met... (1R01CA168653-01A1), EC | MSmed (686547), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Integrative Biology of Tu... (5R01CA085140-07),...

    <jats:title>Abstract</jats:title><jats:p>A hallmark of metastasis is the adaptation of tumor cells to new environments. Although it is well established that the metabolic milieu of the brain is severely deprived of nutrients, particularly the amino acids serine and its ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; Michael Platten; David T. W. Jones; FELICE GIANGASPERO; Marina Ryzhova; Lukas Chavez; Andrey Korshunov; Ori Staszewski; Michael D. Taylor; Matthias Karajannis; ...
    Project: NIH | Multidisciplinary Subspec... (5T32CA163185-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantia...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Outi Maria Keinänen; Naga Vara Kishore Pillarsetty; Delphine Vivier; Anu Airaksinen; Mirkka P Sarparanta;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MICROPLATE SCINTILLATION/... (1S10RR013039-01), AKA | Pretargeted radiopharmace... (298481), NIH | MOUSE GENETICS (2P30CA008748-43), AKA | New radiolabeled molecula... (278056)

    Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and s...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Jason Lewis; Nerissa Viola; Linden Wyatt; Mirkka P Sarparanta;
    Publisher: American Chemical Society (ACS)
    Project: NIH | pHLIP-based agents for pr... (1F32CA186721-01A1), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET Imaging of Cancer wit... (5R01CA138468-04), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), AKA | New radiolabeled molecula... (278056)

    pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two pos...

18 research outcomes, page 1 of 2
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