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43 research outcomes, page 1 of 5
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Professor Rosalind Eeles; Nicola Nicolai; Elizabeth Bancroft; Marta Cardoso; Lidia Feliubadalo; Manuel R. Teixeira; Gareth Evans; Judith Offman;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    Background: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective: To report the utility of ...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access
    Authors:
    Menchero, Sergio; Lopez-Izquierdo, Antonio; Rollan, Isabel; Sainz de Aja, Julio; Andreu, Maria Jose; Kang, Minjung; Adan, Javier; Benedito, Rui; Rayon, Teresa; Hadjantonakis, Anna-Katerina; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms driving cell f... (1R01HD094868-01), NIH | Morphogenesis of mammalia... (5R01DK084391-06), EC | AngioGenesHD (638028)

    The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge about the role of Notch in earl...

  • publication . Article . 2018
    Open Access English
    Authors:
    Vigdis Stefansdottir; Diana M Eccles; Elena Castro; Professor Rosalind Eeles; Nicola Nicolai; Hans Vasen; Elizabeth Bancroft; Jan Lubinski; Lidia Feliubadalo; Manuel R. Teixeira; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Francesco Maura; Niccoló Bolli; Nicos Angelopoulos; Kevin J. Dawson; Daniel Leongamornlert; Inigo Martincorena; Thomas J. Mitchell; Anthony Fullam; Santiago Gonzalez; Raphael Szalat; ...
    Publisher: HAL CCSD
    Project: NIH | MOLECULAR MANIPULATION TO... (5I01BX001584-04), NIH | MOUSE GENETICS (2P30CA008748-43), EC | bECOMiNG (817997), NIH | Career Development Progra... (5P50CA100707-13)

    The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datase...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    null null; Massimo Squatrito; Paolo Codega; Ingo Mellinghoff;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Mechanisms of I... (1R01NS080944-01), NIH | Molecular Mechanisms of D... (5R35NS105109-02)

    The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and  regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and re...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Figlioli, Gisella; Bogliolo, Massimo; Catucci, Irene; Caleca, Laura; Lasheras, Sandra Viz; Pujol, Roser; Kiiski, Johanna I; Muranen, Taru A; Barnes, Daniel; Dennis, Joe; ...
    Publisher: HAL CCSD
    Project: EC | BIORISE (669026), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Center Support Gra... (3P30CA068485-21S4), NIH | Genetic Susceptibility An... (1Z01ES049033-10), NIH | Understanding Ethnic Diff... (5U01CA164973-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Automated Density Measure... (5R01CA177150-03), NIH | Risk and penetrance of mu... (5R01CA192393-02), NIH | Innovative Infrastructure... (5U01CA199277-02), EC | EUROFANCOLEN (305421),...

    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a br...

  • publication . Article . 2018
    Open Access English
    Authors:
    Soslow, Robert A.; Tornos, Carmen; Park, Kay J.; Malpica, Anais; Matias-Guiu, Xavier; Oliva, Esther; Parkash, Vinita; Carlson, Joseph A.; McCluggage, W. Glenn; Gilks, C. Blake;
    Publisher: Lippincott, Williams & Wilkins
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    In this review, we sought to address 2 important issues in the diagnosis of endometrial carcinoma: how to grade endometrial endometrioid carcinomas and how to incorporate the 4 genomic subcategories of endometrial carcinoma, as identified through The Cancer Genome Atlas...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Maria Tello-Lafoz; Katja Srpan; Jing Hu; Yevgeniy Romin; Annalisa Calò; Katharine C. Hsu; Joan Massagué; Morgan Huse; Ekrem Emrah Er;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Synaptic Control of Cytot... (5R01AI087644-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | KIR and HLA in cis and tr... (5R01AI125651-03), NIH | Clinical and Translationa... (5UL1TR002003-02)

    <jats:title>ABSTRACT</jats:title><jats:p>Immune cells identify cancer cells by recognizing characteristic biochemical features indicative of oncogenic transformation. Cancer cells have characteristic mechanical features, as well, but whether these biophysical properties...

  • publication . Article . 2018
    Open Access English
    Authors:
    Murali, Rajmohan; Davidson, Ben; Fadare, Oluwole; Carlson, Joseph A.; Crum, Christopher P.; Gilks, C. Blake; Irving, Julie A.; Malpica, Anais; Matias-Guiu, Xavier; McCluggage, W. Glenn; ...
    Publisher: Lippincott, Williams & Wilkins
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International Society of Gynecological Pathologists in 2016. Re...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Rotemberg, Veronica; Kurtansky, Nicholas; Betz-Stablein, Brigid; Caffery, Liam; Chousakos, Emmanouil; Codella, Noel; Combalia, Marc; Dusza, Stephen; Guitera, Pascale; Gutman, David; ...
    Project: NHMRC | Centre of Research Excell... (1099021), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Personalised Early Detect... (1137127)

    Prior skin image datasets have not addressed patient-level information obtained from multiple skin lesions from the same patient. Though artificial intelligence classification algorithms have achieved expert-level performance in controlled studies examining single image...

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