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21 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shuchi Agrawal Singh; Mads Lerdrup; Ana-Luisa R Gomes; Harmen JG van de Werken; Jens Vilstrup Johansen; Robin Andersson; Albin Sandelin; Kristian Helin; Klaus Hansen;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), WT

    textabstractThe PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (P...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascal Guenel; bernard peissel; mikael eriksson; Thilo Dörk; Anna Jakubowska; Anna Marie Mulligan; Paolo Radice; Sara Olson; Peter Kraft; Florian Heitz; ...
    Project: NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NHMRC | Translation of PALB2 gene... (1029974), NHMRC | Personalized clinical gen... (1061177), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | OVARIAN CANCER RISK AND S... (5K07CA080668-06), WT | Understanding the genetic... (090532), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), EC | COGS (223175),...

    <p style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px auto 10px; line-height: 2.5rem;"><strong style="-webkit-font-smoothing: antialiased; box-sizing: border-box;">Background:</strong> The rarity of mutations in <em style="-webkit-font-smoot...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Frede Donskov;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <p>Background: Adjuvant sunitinib has significantly improved disease-free survival versus placebo in patients with renal cell carcinoma at high risk of recurrence post-nephrectomy (hazard ratio 0.76; 95% confidence interval, 0.59-0.98; two-sided P = 0.03). We report saf...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    María Arufe; Jose Catita; Michele Grassi; Jonas Ellegaard Nielsen; Jose Morales-Corraliza; Shona Pedersen; Mariko Saito; Joshua A. Welsh; Stephen Ginsberg; Javier Mariscal; ...
    Publisher: Elsevier BV
    Project: NIH | Primary Hyperoxaluria (5U54DK083908-03), NIH | Molecular mechanism for b... (5R01DK107652-02), NIH | Mechanisms of Cognitive D... (3P01AG022550-06S1), NIH | UCLA SPORE IN PROSTATE CA... (5P50CA092131-05), NIH | West Virginia IDEA-CTR (1U54GM104942-01), EC | GENTRIS (294340), NIH | INTRACELLULAR TRANSPORT--... (5R37DK037332-23), NIH | Novel Mechanistic Targets... (5P01AG027956-06), NIH | Multidisciplinary Trainin... (5T32DK101357-03), FCT | SFRH/BD/90730/2012 (SFRH/BD/90730/2012),...
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Andreas Prlic; Gustavo Glusman; Michael A Hicks; Peter Rose; Jianjiong Gao;
    Publisher: eScholarship, University of California
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biomedical Data Translato... (3OT3TR002026-01S2)

    The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may ...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Kim, Sarah H.; Da Cruz Paula, Arnaud; Basili, Thais; Dopeso, Higinio; Bi, Rui; Pareja, Fresia; da Silva, Edaise M.; Gularte-Mérida, Rodrigo; Sun, Zhen; Fujisawa, Sho; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; Michael Platten; David T. W. Jones; FELICE GIANGASPERO; Marina Ryzhova; Lukas Chavez; Andrey Korshunov; Ori Staszewski; Michael D. Taylor; Matthias Karajannis; ...
    Project: NIH | Multidisciplinary Subspec... (5T32CA163185-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantia...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Claus Garbe; Per thor Straten; Gennaro Ciliberto; Connie Duong;
    Publisher: BMC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became available for stage IV melanoma patients. Before 2010, the 1-year survival ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Christobel Saunders; Tu Nguyen-Dumont; michael friedlander; Rahul Kumar; Jennifer Stone; Susanne Eriksen Boonen; Mark Jenkins; Barbara Rivera; Pedro Blecua; Salvatore Piscuoglio; ...
    Publisher: NPJ breast cancer
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Translation of PALB2 gene... (1029974), EC | IHCAP (310018), SNSF | The landscape of long non... (PZ00P3_168165)

    Abstract Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the rep...

21 research outcomes, page 1 of 3
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