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7 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiying Fan; Bruno Moltedo; Alejandra Mendoza; Alexey N. Davydov; Mehlika B. Faire; Linas Mazutis; Roshan Sharma; Dana Pe’er; Dmitriy M. Chudakov; Alexander Y. Rudensky;
    Publisher: Rockefeller University Press
    Project: NIH | Self Peptides Bound to MH... (5R37AI034206-18), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Function of Regulatory T ... (5F30AI122721-02)

    Fan et al. have identified a population of recirculating Treg cells with greater suppressive ability and a unique tissue distribution. Using single-cell RNA-seq, they place these Treg cells at the apex of the Treg developmental trajectory and show that similar cells may...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Niccola Funel; Stefano Landi; Federico Canzian; Amethyst Saldia; William Bamlet; Sean Cleary; Rachel Neale; Gabriele Capurso; Sara Olson; Oliver Strobel; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Planning, timing and quit... (1009767), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | Molecular Epidemiology of... (5R01CA109767-04), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NHMRC | Cancer Aetiology and Prev... (1060183), NHMRC | Case-Control Study of Gen... (442302), NIH | Case-Control Study of Pan... (5R01CA098870-03), NIH | CORE--COLORECTAL AND PANC... (5P50CA062924-05), NIH | Mayo Clinic SPORE in Panc... (5P50CA102701-02),...

    Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Alison P. Klein; Brian M. Wolpin; Harvey A. Risch; Rachael Z. Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J. Childs; Jason W. Hoskins; Ashley Jermusyk; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Womens Health Study: Cont... (1R01HL080467-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Vitamin D, Related Genes ... (2R01CA098661-06A2), NIH | Experimental Pathology (5P30CA016087-32), NIH | Pancreatic Cancer Genetic... (5R01CA097075-05), NIH | TRIAL OF ASPIRIN AND VITA... (5R01HL043851-08), NIH | PANCREATIC CANCER CASE CO... (3R01CA059706-01A1S1), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | CALIFORNIA COORDINATED CA... (1U58DP003862-01), NIH | The Womens Health Study: ... (1RC1HL099355-01),...

    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ...

  • publication . Article . 2017
    Open Access
    Authors:
    Martin Lepsik; Anežka Tichá; Petr Pachl; Darren Johnson; Stancho Stanchev;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Membrane protein structur... (MC_U105184322), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), EC | RHOMBOID SUBSTRATES (304154)

    Summary Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeuti...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ajay Gopal; Martin Hutchings; Ranjana Advani; PIER LUIGI ZINZANI;
    Publisher: HAL CCSD
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biostatistics and Bioinfo... (2P50CA097274-06)

    International audience; In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in earl...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Stanislav Dikiy; Rachel Niec;
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Self Peptides Bound to MH... (5R37AI034206-18)

    Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription factors T-bet, GAT...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Christobel Saunders; Tu Nguyen-Dumont; michael friedlander; Rahul Kumar; Jennifer Stone; Susanne Eriksen Boonen; Mark Jenkins; Barbara Rivera; Pedro Blecua; Salvatore Piscuoglio; ...
    Publisher: NPJ breast cancer
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Translation of PALB2 gene... (1029974), EC | IHCAP (310018), SNSF | The landscape of long non... (PZ00P3_168165)

    Abstract Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the rep...

7 research outcomes, page 1 of 1
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