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30 research outcomes, page 1 of 3
  • publication . Preprint . 2018
    Open Access
    Authors:
    Chen, Shi; Wiewiora, Rafal P.; Meng, Fanwang; Babault, Nicolas; Ma, Anqi; Yu, Wenyu; Qian, Kun; Hu, Hao; Zou, Hua; Wang, Junyi; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC , NIH | Discovery of Selective In... (5R01GM122749-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and Inhibition ... (5R01GM126154-02), NIH | The role of reorganizatio... (5R01GM121505-02), EC | ULTRA-DD (115766), WT , NIH | Targeting Lysine Methyltr... (5R01CA218600-02), NIH | Epigenetic Therapy and Pr... (5R01HD088626-02), NIH | Profile substrates and in... (1R01GM096056-01)

    <jats:title>Abstract</jats:title><jats:p>Elucidating conformational heterogeneity of proteins is essential for understanding protein functions and developing exogenous ligands for chemical perturbation. While structural biology methods can provide atomic details of stat...

  • publication . Article . 2016
    Open Access
    Authors:
    Joshua L. Brooks; Liping Xu; Olaf Wiest; Derek S. Tan;
    Publisher: American Chemical Society (ACS)
    Project: NSF | Computational Prediction ... (1058075), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Diversity-Oriented Synthe... (5P41GM076267-06)

    Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energies of competing...

  • publication . Article . 2009
    Open Access
    Authors:
    Paul Tempst;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | INITIATION OF TRANSCRIPTI... (5R01GM037120-17)

    The presence of histone H3 lysine 36 methylation (H3K36me) correlates with actively transcribed genes. In yeast, histone H3K36me mediated by KMT3 (also known as Set2) recruits a histone deacetylase complex, Rpd3s, to ensure the fidelity of transcription initiation. We r...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Teng Fei;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IMMUNOLOGICAL MEMORY TO V... (3U19AI057266-05S1), NIH | Bayesian Network Biomarke... (5R01GM124061-02)

    <jats:title>Summary</jats:title><jats:p>In multicellular organisms, a single zygote develops along divergent lineages to produce distinct cell types. What governs these processes is central to the understanding of cell fate specification and stem cell engineering. Here ...

  • publication . Other literature type . Article . 2019
    Open Access English
    Authors:
    Xin Zhang; Weimin Wang; Hua Yu; Min Wang; Haifang Zhang; Jingnan Lv; Yi-Wei Tang; Barry N. Kreiswirth; Hong Du; Liang Chen;
    Publisher: Centers for Disease Control and Prevention
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The molecular basis of th... (5R01AI090155-05), NIH | Genomic variation in epid... (1R21AI117338-01A1)

    We isolated a New Delhi metallo-β-lactamase 5 (NDM-5)–producing Klebsiella pneumoniae sequence type (ST) 258 strain in southwest China during 2017. The bla(NDM-5) gene was acquired by horizontal plasmid transfer from NDM-5–producing Escherichia coli. We identified genom...

  • publication . Article . 2018
    Open Access English
    Authors:
    Pujuan Deng; Yuqiao Zhou; Junyi Jiang; Haojie Li; Wei Tian; Yinghua Cao; Yan Qin; Jaehoon Kim; Robert G. Roeder; Dinshaw J. Patel; ...
    Publisher: National Academy of Sciences
    Project: NIH | Mechanisms of p53 target ... (5R01CA129325-03), NIH | Nuclear Receptor Coactiva... (5R01DK071900-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Significance The polymerase-associated factor 1 (PAF1) complex is a general transcription elongation factor of RNA polymerase II, which not only regulates various stages of the transcription cycle but also broadly influences gene expression through modulating chromatin ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Thais Basili de Oliveira; Pedro Blecua; Ian Ellis; David Brown; Emad Rakha;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A JEM 1400 Electron Micro... (1S10RR027699-01)

    Granular cell tumors (GCTs) are rare tumors that arise in multiple anatomical locations. Here, the authors investigate the genomics of GCTs, finding inactivating somatic mutations in ATP6AP1 or ATP6AP2 in 72% of the 82 GCTs analyzed. In vitro manipulation of these genes...

  • publication . Article . 2015
    Open Access English
    Authors:
    Santella, Anthony; Kovacevic, Ismar; Herndon, Laura A.; Hall, David H.; Du, Zhuo; Bao, Zhirong;
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Developmental systems biology is poised to exploit large-scale data from two approaches: genomics and live imaging. The combination of the two offers the opportunity to map gene functions and gene networks in vivo at single-cell resolution using cell tracking and quanti...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Jessica Vincent; Carolina Adura; Pu Gao; Antonio Luz; Lodoe Lama; Yasutomi Asano; Rei Okamoto; Toshihiro Imaeda; Jumpei Aida; Katherine Rothamel; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Posttranscriptional regul... (5R01GM104962-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

  • publication . Article . 2013
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Sara Olson; Veronica Setiawan; Jirong Long; Marta Crous-Bou; Amanda Spurdle; Alison Margaret Dunning; ...
    Publisher: Springer Berlin Heidelberg
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Epidemiology of... (1R01CA105212-01A1), NIH | CALIFORNIA TEACHERS STUDY (5R01CA077398-09), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | GENES AND THE ESTROGEN EF... (1R01CA091019-01A1), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOLECULAR EPIDEMIOLOGIC S... (1R01CA090899-01), NHMRC | Molecular Epidemiology of... (339435),...

    Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggestin...

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