Filters (3 )
Download Results
30 research outcomes, page 1 of 3
  • publication . Other literature type . Article . 2016 . Embargo End Date: 24 Aug 2016
    Open Access English
    Authors:
    Iratxe Macias; Leire Arreal; Charles Lawrie; roger gomis; Violeta Serra; Maria Vivanco; Marco Piva; Giacomo Domenici; Ana Rosa Cortazar; Patricia Zúñiga García; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), EC | CANCERMETAB (336343)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Joanna Cyrta; Anke Augspach; Maria Rosaria de Filippo; Davide Prandi; Phillip Thienger; Matteo Benelli; Victoria Cooley; Rohan Bareja; David Wilkes; Sung-Suk Chae; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | SPICE (648670), NIH | Collaborative genomic alt... (1R01CA233650-01), NIH | Towards Understanding Pro... (5R01CA125612-04), SNSF | The landscape of long non... (PZ00P3_168165), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10)

    <jats:title>Abstract</jats:title><jats:p>Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in ∼10% of these patients is through lineage plasticity,...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Andreas Prlic; Gustavo Glusman; Michael A Hicks; Peter Rose; Jianjiong Gao;
    Publisher: eScholarship, University of California
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Biomedical Data Translato... (3OT3TR002026-01S2)

    The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Boire, Adrienne; Brandsma, Dieta; Brastianos, Priscilla K; Le Rhun, Emilie; Ahluwalia, Manmeet; Junck, Larry; Glantz, Michael; Groves, Morris D; Lee, Eudocia Q; Lin, Nancy; ...
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    markdownabstractAbstract Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kasthuri Kannan; Michael Platten; David T. W. Jones; FELICE GIANGASPERO; Marina Ryzhova; Lukas Chavez; Andrey Korshunov; Ori Staszewski; Michael D. Taylor; Matthias Karajannis; ...
    Project: NIH | Multidisciplinary Subspec... (5T32CA163185-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—with substantia...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Christos Hatzis; Salvatore Piscuoglio; Charlotte K Y Ng;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), SNSF | The landscape of long non... (PZ00P3_168165)

    SUMMARY Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the sa...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Kamini Singh; Jianan Lin; Yi Zhong; Antonija Burčul; Prathibha Mohan; Man Jiang; Liping Sun; Vladimir Yong-Gonzalez; Agnes Viale; Justin R. Cross; ...
    Publisher: Rockefeller University Press
    Project: NIH | The genomic pathogenesis ... (5R01CA190384-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Towards The Chemotherapy-... (1R01CA183876-01), NIH | RNA Structurome in Post-T... (5R35GM124998-02), NIH | Exploring oncogenic trans... (5R01CA207217-03)

    Singh et al. show that MYC affects mRNA translation efficiency and start-site selection. Notable examples include the translation of mRNAs encoding most proteins of the electron transport chain and aberrant translation initiation site usage in the CD19 receptor that all...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Helen Lindsay; Nathaniel Campbell; Christian Mosimann; Lorenz Studer;
    Publisher: The Company of Biologists
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Malignant melanoma studie... (5F31CA196305-02), EC | MOSIMANN ZEBRAFISH (631984), NIH | Investigating the Role of... (1F99CA212436-01), SNSF | Deciphering the control o... (PP00P3_139093), NIH | The role of melanocyte pr... (1K08AR055368-01A2), NIH | Evolutionary dynamics of ... (1DP2CA186572-01)

    Summary: Here, we developed Transgene Electroporation in Adult Zebrafish (TEAZ), a method that enables researchers to study cancer and metastasis by introducing DNA elements focally into somatic adult tissue.

  • publication . Preprint . 2020
    Open Access
    Authors:
    Baggiolini, Arianna; Callahan, Scott J.; Trieu, Tuan; Tagore, Mohita M.; Montal, Emily; Weiss, Joshua M.; Tischfield, Sam E.; Fan, Yujie; Campbell, Nathaniel R.; Saurat, Nathalie; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Malignant melanoma studie... (5F31CA196305-02), SNSF | The roles of aging in tum... (P400PB_180672), NIH | Dissecting the complexity... (1R01CA229215-01), NIH | Dissecting the Ecology of... (1F30CA220954-01A1), NIH | TRAINING PROGRAM IN MOLEC... (5T32GM008539-08), SNSF | Distinguishing the Ageing... (P2ZHP3_171967), NIH | The role of melanocyte pr... (1K08AR055368-01A2), NIH | Investigating the Role of... (1F30CA236442-01),...

    <jats:title>Abstract</jats:title><jats:p>Oncogenes are only transforming in certain cellular contexts, a phenomenon called oncogenic competence. The mechanisms regulating this competence remain poorly understood. Here, using a combination of a novel human pluripotent st...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Mark Rubin; Dr. Judith Balmaña; Pasquale Rescigno; Joaquin Mateo;
    Publisher: National Academy of Sciences NAS
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical Development of T... (5P50CA097186-13), EC | SPICE (648670), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | SPORE in Prostate Cancer (5P50CA090381-05), NIH | Towards Understanding Pro... (5R01CA125612-04), NIH | A Precision Medicine Appr... (5P50CA186786-02)

    Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcript...

30 research outcomes, page 1 of 3
Last index information