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47 research outcomes, page 1 of 5
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Shuji Ogino; Brendan Guercio; Donna Niedzwiecki;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Multidisciplinary Trainin... (5T32HL125232-02), NIH | NCTN Lead Academic Partic... (5U10CA180867-04), NIH | Alliance for Clinical Tri... (3U10CA180821-02S2), NIH | Network Lead Academic Par... (3U10CA180791-04S1), NIH | Accelerating Transdiscipl... (5R35CA197735-04), NIH | Statistics and Data Cente... (5U10CA180882-02), NIH | CANCER AND LEUKEMIA GROUP... (5U10CA060138-04), NIH | Southeast Clinical Oncolo... (5UG1CA189858-02), NIH | Role of Vitamin D, Inflam... (5K07CA148894-02), NIH | ECOG-ACRIN Operations Cen... (3U10CA180820-02S3),...

    Purpose Observational studies have demonstrated increased colon cancer recurrence and mortality in states of excess energy balance, as denoted by factors including sedentary lifestyle, diabetes, increased dietary glycemic load, and increased intake of sugar-sweetened be...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Amos, CI; Dennis, Joe; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; Hunter, DJ; Sellers, TA; Gruber, SB; ...
    Publisher: American Association for Cancer Research
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA081488-05), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast Cancer Family Regi... (1UM1CA164920-01A1), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2), EC | RADIOGENFF (656144), NIH | Epidemiologic Studies (5U19CA148107-04),...

    Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The...

  • publication . Article . 2013
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Sara Olson; Veronica Setiawan; Jirong Long; Marta Crous-Bou; Amanda Spurdle; Alison Margaret Dunning; ...
    Publisher: Springer Berlin Heidelberg
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular Epidemiology of... (1R01CA105212-01A1), NIH | CALIFORNIA TEACHERS STUDY (5R01CA077398-09), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | GENES AND THE ESTROGEN EF... (1R01CA091019-01A1), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | MOLECULAR EPIDEMIOLOGIC S... (1R01CA090899-01), NHMRC | Molecular Epidemiology of... (339435),...

    Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggestin...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Danussi, Carla; Bose, Promita; Parthasarathy, Prasanna T.; Silberman, Pedro C.; Van Arnam, John S.; Vitucci, Mark; Tang, Oliver Y.; Heguy, Adriana; Wang, Yuxiang; Chan, Timothy A.; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), CIHR , NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | Credentialing murine mode... (5R01CA204136-02)

    ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Sun Young Rha;
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    ABSTRACT Background RECORD-3 compared everolimus and sunitinib as first-line therapy, and the sequence of everolimus followed by sunitinib at progression compared with the opposite (standard) sequence in patients with metastatic renal cell carcinoma (mRCC). This final o...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Mark W. Moyle; Kristopher M. Barnes; Manik Kuchroo; Alex Gonopolskiy; Leighton H. Duncan; Titas Sengupta; Lin Shao; Min Guo; Anthony Santella; Ryan Christensen; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Molecular and cellular me... (3F32NS098616-01S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Powering the Brain: the C... (1DP1NS111778-01), NIH | Cellular and molecular me... (2R01NS076558-06A1), NIH | WormGuides: a resource fo... (3R24OD016474-02S1)

    <jats:title>Summary</jats:title><jats:p>Neuropil is a fundamental form of tissue organization within brains<jats:sup>1</jats:sup>. In neuropils, densely packed neurons synaptically interconnect into precise circuit architecture<jats:sup>2,3</jats:sup>, yet the structura...

  • publication . Other literature type . Preprint . Article . 2019
    Open Access
    Authors:
    Xiao-Chuan Cai; Tuo Zhang; Eui-jun Kim; Ming Jiang; Ke Wang; Junyi Wang; Shi Chen; Nawei Zhang; Hong Wu; Fengling Li; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NSERC , NIH | Protein Arginine Methylat... (1R01CA213293-01), EC | ULTRA-DD (115766), NIH | Statistical Evaluation an... (1R21CA214845-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), WT , NIH | Interrogating Functions o... (1R01GM120570-01), NIH | Protein Arginine Methylat... (1R01CA236356-01), NIH | Profile substrates and in... (1R01GM096056-01)

    CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with pro-drug properties....

  • publication . Article . 2016
    Open Access
    Authors:
    Permuth, J. B.; Reid, B.; Earp, M.; Chen, Y. A.; Monteiro, A. N. A.; Chen, Z.; Chenevix-Trench, G.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; ...
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05),...

    RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypo...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Gerald Zamponi; Maria Gandini;
    Publisher: BioMed Central
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Alternative pre-mRNA spli... (5R01DA042888-02), NIH | Mapping mu agonist-induce... (1R21DA046714-01), NIH | Behavioral Pharmacology o... (2T32DA007242-26), CIHR

    Abstract We have examined the regulation of mutually exclusive Cav2.2 exon 37a and b variants by the mouse μ-opioid receptor (mMOR) C-terminal splice variants 1, 1C and 1O in tsA-201 cells. Electrophysiological analyses revealed that both channel isoforms exhibit DAMGO-...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Josh Fass; David A. Sivak; Gavin E. Crooks; Kyle A. Beauchamp; Benedict Leimkuhler; John D. Chodera;
    Project: NSERC , NIH | The role of reorganizatio... (5R01GM121505-02), NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Data-Driven Coarse-Graini... (EP/P006175/1), NSF | D3SC: EAGER: Collaborativ... (1738979)

    <jats:title>Abstract</jats:title><jats:p>While Langevin integrators are popular in the study of equilibrium properties of complex systems, it is challenging to estimate the timestep-induced discretization error: the degree to which the sampled phase-space or configurati...

47 research outcomes, page 1 of 5
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