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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Timothy Vartanian; Jennifer R. Linden; Eric F. Schmidt; Marissa Valenzuela; Francisco A. Uzal; Claudia Flores; Adam O Michel; Sebastian Dobrow;
    Publisher: Public Library of Science
    Project: NIH | Profiling axonal RNA in v... (1R21NS105047-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Molecular phenotyping of ... (5R01NS091722-03)

    Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this process are not...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Kristen M. Cunanan; Amber L. Simpson; Mithat Gonen; Richard K. G. Do; Maeve A. Lowery; Jayasree Chakraborty; Eileen M. O’Reilly; Joanna G. Escalon; Liana Langdon-Embry; Peter J. Allen;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in the United States with a five-year survival rate of 7.2% for all stages. Although surgical resection is the only curative treatment, currently we are unable to differentiate between resectable ...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Thomas Reiner; Wolfgang A. Weber; Christian Brand; Beatriz Salinas; Christopher Irwin; Yasiri Portorreal; Pooja Desai; Yachao Zhang;
    Publisher: Neoplasia Press, Inc. Published by Elsevier Inc.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    AbstractNew intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of...

  • publication . Article . 2017
    Open Access English
    Authors:
    Vaios Hatzoglou; Andrei I. Holodny; Antonio Omuro; Alpesh Mehta; Mariza Daras; Kathryn Beal; Jamie Tisnado; Kyung K. Peck;
    Publisher: John Wiley and Sons Inc.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI. Dynamic contrast‐enhanced (DCE)‐MRI can assess tumor microvasculature and has demonstrated utility in characterizing primar...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Tari A. King; Angela Di Giannatale; Maneesh Jain; Bruno Costa-Silva; Paul M. Grandgenett; Ayuko Hoshino; Leonard H. Wexler; Lindsay A. Pharmer; Kunihiro Uryu; Mina J. Bissell; ...
    Publisher: eScholarship, University of California
    Project: NIH | Characterization and Func... (1U01CA169538-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Exosome-mediated Transfer... (5R01CA169416-03)

    © 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour c...

  • publication . Other literature type . Article . 2020
    Open Access
    Authors:
    Valentina Fossati; Anna Rodina; Mark Dunphy; Wenjie Luo; Maria Carmen Inda; Maria Carmen Inda; Sonia Sequeira; Thomas A. Neubert; Natalia V. De Marco García; Afsar Barlas; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | LTQ-Orbitrap Mass Spectro... (1S10RR027990-01A1), NIH | Cell and molecular pathob... (3P01AG017617-07S1), NIH | Biomarkers for predicting... (5R01CA172546-05), NIH | The role of Hsp 90 in Alz... (5K01AG032364-05), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Small molecule Hsp90 inhi... (5U01AG032969-04), NIH | Cellular and Molecular Me... (7R01AG043375-03), NIH | A chemical chaperomics pl... (1R56AG061869-01), NIH | CORE--STATISTICS AND DATA... (1P01AG014449-02)

    Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer’s disease (AD). Here we use cellular and animal models as well as human biospecimens to show that AD-related stressors ...

6 research outcomes, page 1 of 1