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57,352 research outcomes, page 1 of 5,736
  • publication . Article . 2019
    Open Access English
    Authors:
    Mengrelis, K.; Lau, C-I; Rowell, J.; Solanki, A.; Norris, S.; Ross, S.; Ono, M.; Outram, S.; Crompton, T.;
    Publisher: FRONTIERS MEDIA SA
    Project: WT | Thymus transplantation fo... (094255), RCUK | Hedgehog signalling in pe... (MR/P000843/1)

    Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset distribution. Hh-...

  • publication . Article . 2014
    Open Access English
    Authors:
    Matthias Baud;
    Project: FCT | SFRH/BD/81735/2011 (SFRH/BD/81735/2011), EC | DRUGE3CRLS (311460), RCUK | DISSECTING AND EXPLOITING... (BB/G023123/1), EC | PVHL-CRL (275683)

    Modulation of protein−protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with PPI target sites pose significant ch...

  • publication . Article . 2014
    Open Access English
    Authors:
    Mairi E. Sandison; K. Tveen Jensen; F. Gesellchen; J. M. Cooper; A. R. Pitt;
    Project: RCUK | Next Generation Analytica... (EP/I017887/1)

    Reversible phosphorylation plays a key role in numerous biological processes. Mass spectrometry-based approaches are commonly used to analyze protein phosphorylation, but such analysis is challenging, largely due to the low phosphorylation stoichiometry. Hence, a number...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Hesketh, E; Tiede, C; Adamson, H; Adams, T; Byrne, M; Meshcheriakova, Y; Kruse, I; McPherson, M; Lomonossoff, G; Tomlinson, D; ...
    Publisher: Nature Publishing Group
    Project: RCUK | Untangling the processes ... (BB/L021250/1), RCUK | Untangling the processes ... (BB/L020955/1), WT | New infrastructure for EM... (090932), RCUK | Enhanced Research Capacit... (BBS/E/J/000PR9794), RCUK | Exploiting the power of h... (BB/R00160X/1)

    Abstract Plant viruses can cause devastating losses to agriculture and are therefore a major threat to food security. The rapid identification of virally-infected crops allowing containment is essential to limit such threats, but plant viral diseases can be extremely ch...

  • publication . Article . Preprint . 2012
    Open Access
    Authors:
    Imada, K.; Wilson, H. R.;
    Publisher: AIP Publishing
    Project: RCUK | The Interaction of Transp... (EP/H049460/1)

    Comment: Accepted by Physics of Plasmas, 18 pages, 7 figures

  • publication . Article . 2011
    Open Access English
    Authors:
    Talmud, P. J.; Cooper, J. A.; Gaunt, T.; Holmes, M. V.; Shah, S.; Palmen, J.; Drenos, F.; Shah, T.; Kumari, M.; Kivimaki, M.; ...
    Publisher: Springer Verlag
    Project: NIH | English Longitudinal Stud... (3R01AG017644-14S2), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), NIH | SOCIAL AND OCCUPATIONAL I... (5R01HL036310-09), RCUK | Public health application... (G0802432)

    Aims/hypothesis We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. Methods Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Gryshchenko, Oleksiy; Gerasimenko, Julia V.; Peng, Shuang; Gerasimenko, Oleg V.; Petersen, Ole H.;
    Publisher: Wiley
    Project: RCUK | MICA: Calcium signalling,... (MR/J002771/1)

    Key points Ca2+ signalling in different cell types in exocrine pancreatic lobules was monitored simultaneously and signalling responses to various stimuli were directly compared.Ca2+ signals evoked by K+‐induced depolarization were recorded from pancreatic nerve cells. ...

  • publication . Article . 2017
    Open Access
    Authors:
    Darrington, Michael; Dalmay, Tamas; Morrison, Neil I.; Chapman, Tracey;
    Publisher: Wiley
    Project: RCUK | dsRNA induced traits for ... (BB/N50418X/1)

    RNA interference (RNAi) of insect pests is reviewed and its potential for implementing Sterile Insect Technique (SIT)-related control is considered. The molecular mechanisms that support RNAi in pest species are reviewed in detail, drawing on literature from a range of ...

  • publication . Book . 2016
    Open Access English
    Authors:
    Tunstall, Rebecca Katharine; Swaffield, Joanna Kate;
    Publisher: Commissioned Report for JRF/JRHT, CYC & YSJU
    Project: RCUK | Identifying sustainable p... (ES/L002086/1)

    As part of the ESRC Knowledge Exchange project “Identifying sustainable pathways out of in-work poverty” a qualitative in-depth follow-up survey to the main quantitative poverty survey was undertaken. This follow-up survey sample was drawn from those employees providing...

  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Armstrong, David J.; Lopez, Théo A.; Adibekyan, Vardan; Booth, Richard A.; Bryant, Edward M.; Collins, Karen A.; Deleuil, Magali; Emsenhuber, Alexandre; Huang, Chelsea X.; King, George W.; ...
    Publisher: Nature Publishing
    Project: RCUK | Irradiated atmospheres of... (ST/R003726/1)

    Comment: Published in Nature. This is a preprint of the article, before minor changes made during the refereeing and editing process. The published PDF is at https://www.nature.com/articles/s41586-020-2421-7 and can be accessed for free by following this link: https://r...

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