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205 research outcomes, page 1 of 21
  • publication . Article . 2018
    Open Access English
    Authors:
    Janet Piñero; Abel Gonzalez-Perez; Emre Guney; Joaquim Aguirre-Plans; Ferran Sanz; Baldo Oliva; Laura I. Furlong;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | MedBioinformatics (634143), EC | eTRANSAFE (777365), EC | TransQST (116030), EC | ELIXIR-EXCELERATE (676559)

    Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The characterization of drug targets, drug metabolism pr...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Xiaoyuan Lin; Evy Beckers; Séan Mc Cafferty; Yannick Gansemans; Katarzyna Joanna Szymańska; Krishna Chaitanya Pavani; João Paulo Portela Catani; Filip Van Nieuwerburgh; Dieter Deforce; Petra De Sutter; ...
    Publisher: Frontiers Media S.A.
    Project: EC | REP-BIOTECH (675526)

    Recently, secreted microRNAs (miRNAs) have received a lot of attention since they may act as autocrine factors. However, how secreted miRNAs influence embryonic development is still poorly understood. We identified 294 miRNAs, 114 known, and 180 novel, in the conditione...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Eric R. Hester; Mike S. M. Jetten; Cornelia U. Welte; Sebastian Lücker;
    Project: EC | ECO-MOM (339880), NWO | Microbes for health and e... (2300181602)

    AbstractThe majority of microbial communities consist of hundreds to thousands of species, creating a massive network of organisms competing for available resources within an ecosystem. In natural microbial communities it appears that many microbial species have highly ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Vandeputte, Marc,; Haffray, Pierrick;
    Persistent Identifiers
    Project: EC | FISHBOOST (613611)

    International audience; Since the middle of the 1990s, parentage assignment using microsatellite markers has been introduced as a tool in aquaculture breeding. It now allows close to 100% assignment success, and offered new ways to develop aquaculture breeding using mix...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Kathrin Klein; Ulrich M. Zanger;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | FIGHTINGDRUGFAILURE (238132)

    CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its prominent expression in liver and gut and because of its broad substrate specificity, which includes drugs from most therapeutic categories and many endogenous substances. Expression an...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Mathieu Besson; François Allal; Béatrice Chatain; Alain Vergnet; Frédéric Clota; Marc Vandeputte;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | EMBRIC (654008)

    Measuring individual feed intake of fish in farms is complex and precludes selective breeding for feed conversion ratio (FCR). Here, we estimated the individual FCR of 588 sea bass using individual rearing under restricted feeding. These fish were also phenotyped for th...

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  • publication . Article . 2012
    Open Access
    Authors:
    Carmela Dell'Aversana; Lucia Altucci;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | BLUEPRINT (282510)

    MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides (nt) long able to fine-tune post-transcriptional gene expression. Extensive investigation into biogenesis, mechanism of action and functions of miRNAs has clearly revealed their prompt control in development...

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  • publication . Article . 2020
    Open Access
    Authors:
    Brigid Unim; Corrado De Vito; Julie Hagan; Paolo Villari; Bartha Maria Knoppers; Ma'n H. Zawati;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | PRECeDI (645740), WT

    Background Research in the field of genomics and genetics has evolved in recent years and so has the demand of consumers who are increasingly interested in genomic prediction of diseases and various traits. The aim of this study is to identify genetic service delivery m...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Pieter W. Knap; Antti Kause;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | FISHBOOST (613611)

    Feed incurs most of the cost of aquaculture production, so feed efficiency (FE) improvement is of great importance. Our aim is to use work done in pigs to formulate a logical framework for assessing the most useful component traits influencing feed intake (FI) and effic...

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  • publication . Article . 2020
    Open Access
    Authors:
    Yousra Ben Zouari; Angeliki Platania; Anne Molitor; Tom Sexton;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: ANR | France-Génomique (ANR-10-INBS-0009), EC | CHROMTOPOLOGY (678624), ANR | UNISTRA (ANR-10-IDEX-0002), ANR | INRT (ANR-10-LABX-0030)

    It is established that transcription of many metazoan genes is regulated by distal regulatory sequences beyond the promoter. Enhancers have been identified at up to megabase distances from their regulated genes, and/or proximal to or within the introns of unregulated ge...

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205 research outcomes, page 1 of 21