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1,657 research outcomes, page 1 of 166
  • publication . Article . 2013
    Open Access English
    Authors:
    Sofiya Kolusheva; Jeff F. Miller; Ronit Bitton; G. Davidov; Atish Ganguly; Raz Zarivach; Hadassa Shaked; Jordan H. Chill; C. Guttman;
    Persistent Identifiers
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: EC | T3SSBTEA (239182), EC | PCUBE (227764)

    BteA, a 69-kDa cytotoxic protein, is a type III secretion system (T3SS) effector in the classical Bordetella, the etiological agents of pertussis and related mammalian respiratory diseases. Currently there is limited information regarding the structure of BteA or its su...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Uwizeye, Clarisse; Decelle, Johan; Jouneau, Pierre-Henri; Flori, Serena; Gallet, Benoit; Keck, Jean-Baptiste; Bo, Davide Dal; Moriscot, Christine; Seydoux, Claire; Chevalier, Fabien; ...
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (17-EURE-0003), EC | CORBEL (654248), EC | ChloroMito (833184), ANR | MoMix (ANR-17-CE05-0029)

    Eukaryotic phytoplankton have a small global biomass but play major roles in primary production and climate. Despite improved understanding of phytoplankton diversity and evolution, we largely ignore the cellular bases of their environmental plasticity. By comparative 3...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Jennifer Timm; Julien Pérard; Barbara Zambelli; Céline Brochier-Armanet; Christine Cavazza; Stefano Ciurli; S. Ollagnier-de-Choudens;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    International audience; In Rhodospirillum rubrum, maturation of Carbon Monoxide Dehydrogenase (CODH) requires three accessory proteins, CooC, CooT and CooJ, dedicated to nickel insertion into the active site, which is constituted by a distorted [NiFe$_3$S$_4$] cubane co...

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  • publication . Other literature type . Article . 2012
    Open Access
    Authors:
    Wolfgang R. Streit; Marrit Eckstein; Uwe T. Bornscheuer; Filip Kovacic; Andreas Liese; Christel Schmeisser; Benjamin Lauinger; Yuliya Dall Antonia; Jennifer Chow; Ina Menyes; ...
    Publisher: Public Library of Science (PLoS)
    Project: EC | PCUBE (227764)

    Triacylglycerol lipases (EC 3.1.1.3) catalyze both hydrolysis and synthesis reactions with a broad spectrum of substrates rendering them especially suitable for many biotechnological applications. Most lipases used today originate from mesophilic organisms and are susce...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Teemu Haikarainen; Ezeogo Obaji; Harikanth Venkannagari; Y. Nkizinkiko; Lari Lehtiö; Mohit Narwal; Mohit Narwal; Hao Wei Lee;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: EC | BIOSTRUCT-X (283570)

    Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate β-catenin levels in many cancer cell lines and human embryonic stem cells. Here we confirm that WIKI4 is a high potency tankyrase ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Nina S. Atanasova; Hanna M. Oksanen; Janne J. Ravantti; Maija K. Pietilä; Tatiana A. Demina; Dennis H. Bamford; Julija Svirskaitė;
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: AKA | Structure brings order to... (255342), AKA | Finnish participation in ... (272853), AKA | Structure brings order to... (283072)

    IMPORTANCE Under conditions of extreme salinity, the majority of the organisms present are archaea, which encounter substantial selective pressure, being constantly attacked by viruses. Regardless of the enormous viral sequence diversity, all known viruses can be cluste...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Radamaker, Lynn; Lin, Yin-Hsi; Annamalai, Karthikeyan; Huhn, Stefanie; Hegenbart, Ute; Schönland, Stefan O.; Fritz, Günter; Schmidt, Matthias; Fändrich, Marcus;
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: EC | iNEXT (653706)

    Amyloid fibrils derived from antibody light chains are key pathogenic agents in systemic AL amyloidosis. They can be deposited in multiple organs but cardiac amyloid is the major risk factor of mortality. Here we report the structure of a λ1 AL amyloid fibril from an ex...

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  • publication . Article . 2013
    Open Access
    Authors:
    Jason R. Swedlow; Ingvar Lagerstedt; William J. Moore; Gerard J. Kleywegt; Eduardo Sanz-García; Ardan Patwardhan; Christoph Best;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: WT | The Open Microscopy Envir... (095931), WT | Protein Data Bank in Euro... (088944), WT | The Open Microscopy Envir... (085982), NIH | Unified Data Resource for... (5R01GM079429-05), EC | BIOMEDBRIDGES (284209)

    AbstractThe Protein Data Bank in Europe (PDBe) has developed web-based tools for the visualisation and analysis of 3D electron microscopy (3DEM) structures in the Electron Microscopy Data Bank (EMDB) and Protein Data Bank (PDB). The tools include: (1) a volume viewer fo...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Pedro L. Rodriguez; Florine Dupeux; Regina Antoni; Lesia Rodriguez; Miguel González-Guzmán; José A. Márquez; Katja Betz; Julia Santiago;
    Publisher: Elsevier
    Project: EC | PCUBE (227764)

    Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors abl...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Pascale Tacnet-Delorme; Julie Gabillet; Julie Gabillet; Julie Gabillet; Simon Chatfield; Simon Chatfield; Simon Chatfield; Simon Chatfield; Nathalie Thieblemont; Nathalie Thieblemont; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can poten...

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1,657 research outcomes, page 1 of 166