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204 research outcomes, page 1 of 21
  • publication . Article . 2017
    Open Access English
    Authors:
    Grigory Sharov; Karine Voltz; Alexandre Durand; Olga Kolesnikova; Gabor Papai; Alexander G. Myasnikov; Annick Dejaegere; Adam Ben Shem; Patrick Schultz;
    Publisher: Nature Publishing Group
    Project: ANR | UNISTRA (ANR-10-IDEX-0002), ANR | INRT (ANR-10-LABX-0030), ANR | Bip:Bip (ANR-10-BINF-0003)

    The transcription co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activators and by chromatin modifications to promote pre-initiation complex formation. The yeast Tra1 subunit is the major target of acidic activators such as...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Guillaume Tetreau; Anne-Sophie Banneville; Elena A. Andreeva; Aaron S. Brewster; Mark S. Hunter; Raymond G. Sierra; Jean-Marie Teulon; I.D. Young; Niamh Burke; Tilman A. Grünewald; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | X-in-vivo (ANR-17-CE11-0018), NIH | DIALS: New Computational ... (5R01GM117126-02), NIH | Pacific Southwest Regiona... (1U01CK000516-01), NIH | A SYNCHROTRON RADIATION B... (5P41RR001209-14), NIH | Molecular Improvement of ... (5R01AI045817-04), NIH | A Synchroton Radiation St... (8P41GM103393-33), ANR | CBH-EUR-GS (ANR-17-EURE-0003), NIH | Highly Improved Bacterial... (1U01AI054778-01), ANR | DynOCP (ANR-18-CE11-0005)

    Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Ai Woon Yee; Martine Moulin; Nina Breteau; Michael Haertlein; Edward P. Mitchell; Jonathan B. Cooper; Elisabetta Boeri Erba; V. Trevor Forsyth;
    Project: UKRI | Deuteration Initiative fo... (EP/C015452/1)

    Abstract It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Odermatt, Nina,; Lelli, Moreno; Herrmann, Torsten; Abriata, Luciano,; Japaridze, Aleksandre; Voilquin, Hubert; Singh, Rajkumar; Piton, Jérémie; Emsley, Lyndon; Dietler, Giovanni; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    Abstract In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to A...

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  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Project: ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2016
    Open Access English
    Authors:
    K.K. Rasmussen; Kristian E. H. Frandsen; Elisabetta Boeri Erba; Margit Pedersen; Anders K. Varming; Karin Hammer; Mogens Kilstrup; Peter W. Thulstrup; Martin Blackledge; Malene Ringkjøbing Jensen; ...
    Publisher: Deutsches Elektronen-Synchrotron, DESY, Hamburg
    Project: EC | BIOSTRUCT-X (283570)

    Published by Nature Publishing Group, London

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  • publication . Other literature type . Article . 2018
    Open Access English
    Authors:
    Katharina Weinhäupl; Martha Brennich; Uli Kazmaier; Joël Lelièvre; Lluis Ballell; Alfred L. Goldberg; Paul Schanda; Hugo Fraga;
    Persistent Identifiers
    Publisher: American Society for Biochemistry and Molecular Biology

    Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill Mycobacterium tuberculosis pe...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Piotr Gerlach; Hélène Malet; Stephen Cusack; Juan Reguera;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | V-RNA (322586)

    Highlights • Bunyavirus polymerase binds its complementary 3′ and 5′ vRNA ends in distinct sites • 5′ vRNA binding allosterically structures and activates the polymerase catalytic site • Distinct template/product exit tunnels explain RNA synthesis in a circularized RNP ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Conrad V. Simoben; Dina Robaa; Alokta Chakrabarti; Karin Schmidtkunz; Martin Marek; Julien Lancelot; Srinivasaraghavan Kannan; Jelena Melesina; Tajith B. Shaik; Raymond J. Pierce; ...
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | A-PARADDISE (602080), EC | SETTREND (241865)

    International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the cr...

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  • publication . Article . 2017
    Open Access English
    Authors:
    J. Retel; Andrew J. Nieuwkoop; Matthias Hiller; Victoria A. Higman; Emeline Barbet-Massin; Jan Stanek; Loren B. Andreas; W. Trent Franks; Barth-Jan van Rossum; Kutti R. Vinothkumar; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | BIO-NMR (261863)

    β-barrel proteins mediate nutrient uptake in bacteria and serve vital functions in cell signaling and adhesion. For the 14-strand outer membrane protein G of Escherichia coli, opening and closing is pH-dependent. Different roles of the extracellular loops in this proces...

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204 research outcomes, page 1 of 21