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128 research outcomes, page 1 of 13
  • publication . Article . 2016
    Open Access English
    Authors:
    Graham P Taylor; Lucy Cook; Aileen Rowan; Anat Melamed; Charles Bangham;
    Publisher: Public Library of Science
    Project: RCUK | Regulation of clonality i... (MR/K019090/1), WT , WT | Regulation of retroviral ... (100291)

    There is growing evidence that CD8+ cytotoxic T lymphocyte (CTL) responses can contribute to long-term remission of many malignancies. The etiological agent of adult T-cell leukemia/lymphoma (ATL), human T lymphotropic virus type-1 (HTLV-1), contains highly immunogenic ...

  • publication . Article . Doctoral thesis . 2016
    Open Access
    Authors:
    Michael Vanlandewijck; Katerina Pardali;
    Publisher: Rockefeller University Press
    Project: WT

    <jats:p>Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Not...

  • publication . Article . Other literature type . Doctoral thesis . 2018
    Open Access
    Authors:
    Yamada, Satoshi; Nakao, Tomohiro; Ikari, Keisuke; Kuwano, Masumi; Murayama, Keitaro; Tomiyama, Hirofumi; Hasuzawa, Suguru; Togao, Osamu; Hiwatashi, Akio; Kanba, Shigenobu;
    Publisher: Public Library of Science (PLoS)
    Project: WT

    BACKGROUND: Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormali...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Dorit Hockman; Vanessa Chong-Morrison; Stephen A. Green; Daria Gavriouchkina; Ivan Candido-Ferreira; Irving T. C. Ling; Ruth M. Williams; Chris T. Amemiya; Jeramiah J. Smith; Marianne E. Bronner; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Functional analysis of pr... (1R01GM104123-01A1), NIH | Germline sequence resourc... (5R24GM095471-02), WT

    An understanding of the ancestral state of the neural crest (NC) gene regulatory network (GRN) gives insight into vertebrate evolution. Here, the authors use transcriptomic and chromatin accessibility analyses of the lamprey NC, as well as cross-species enhancer assays,...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Soichiro Kitamura; Hitoshi Shimada; Fumitoshi Niwa; Hironobu Endo; Hitoshi Shinotoh; Keisuke Takahata; Manabu Kubota; Yuhei Takado; Shigeki Hirano; Yasuyuki Kimura; ...
    Publisher: BMJ Publishing Group
    Project: WT

    <jats:sec><jats:title>Objective</jats:title><jats:p>Apathy is a common neuropsychological symptom in Alzheimer’s disease (AD), and previous studies demonstrated that neuronal loss and network disruption in some brain regions play pivotal roles in the pathogenesis of apa...

  • publication . Article . 2016
    Open Access English
    Authors:
    William Earnshaw; Nuno Martins;
    Project: WT | The Cellular and Molecula... (080458), FCT | SFRH/BD/62092/2009 (SFRH/BD/62092/2009), WT | The role of non-histone p... (107022)

    Centromeres are characterized by the centromere-specific H3 variant CENP-A, which is embedded in chromatin with a pattern characteristic of active transcription that is required for centromere identity. It is unclear how centromeres remain transcriptionally active despi...

  • publication . Article . Other literature type . Preprint . 2020
    Open Access English
    Authors:
    Nakano, Takashi; Takamura, Masahiro; Ichikawa, Naho; Okada, Go; Okamoto, Yasumasa; Yamada, Makiko; Suhara, Tetsuya; Yamawaki, Shigeto; Yoshimoto, Junichiro;
    Project: WT

    <jats:p>Resting-state fMRI has the potential to find abnormal behavior in brain activity and to diagnose patients with depression. However, resting-state fMRI has a bias depending on the scanner site, which makes it difficult to diagnose depression at a new site. In thi...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Edgar, James; Manna, Paul; Nishimura, Shinichi; Banting, George; Robinson, Margaret;
    Publisher: eLife Sciences Organisation, Ltd.
    Project: WT | High Resolution Imaging i... (093026), WT , WT | Cellular Medicine at the ... (100140), WT | Coated vesicle adaptors. (086598)

    Exosomes are extracellular vesicles that are released when endosomes fuse with the plasma membrane. They have been implicated in various functions in both health and disease, including intercellular communication, antigen presentation, prion transmission, and tumour cel...

  • publication . Article . Doctoral thesis . 2017
    Open Access
    Authors:
    Kurogi, Syuji; Sekimoto, Tomohisa; Funamoto, Taro; Ota, Tomomi; Nakamura, Shihoko; Nagai, Takuya; Nakahara, Mai; Yoshinobu, Kumiko; Araki, Kimi; Araki, Masatake; ...
    Publisher: Springer Science and Business Media LLC
    Project: WT

    Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap...

  • <p>Mice lacking three epidermal barrier proteins-envoplakin, periplakin and involucrin-(EPI-/- mice) have a defective cornified layer, reduced epidermal γδ T cells, increased dermal CD4+ T cells and are resistant to developing skin tumours. The tumour-protective mechani...

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