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8,483 research outcomes, page 1 of 849
  • publication . Article . 2019
    Open Access
    Authors:
    Evie Maifoshie; Robert Sampson; Marta S Abreu Paiva; Michela Noseda; Sian Harding; daniel stuckey;
    Project: WT , NIH | TGF Beta-activated Kinase... (5R01HL052555-12), EC | CADRE (233158), RCUK | MRC-BHF Cardiovascular St... (G0901467)

    Summary Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has been ha...

  • publication . Article . 2013
    Open Access
    Authors:
    Jonathan Barker; Paola Di Meglio;
    Publisher: Elsevier BV
    Project: WT | Factors Defining T Cell M... (078173), RCUK | Functional characterisati... (G0601387)

    We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis. Moreover, we have recently shown impaired IL-23-induced IL-17A production a...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Richard J. Allen; Beatriz Guillen-Guio; Justin M. Oldham; Shwu-Fan Ma; Amy Dressen; Megan L. Paynton; Luke M. Kraven; Ma'en Obeidat; Xuan Li; Michael Ng; ...
    Project: NIH | Obstructive Sleep Apnea a... (1R01HL137234-01A1), NIH | UCLA Clinical Translation... (3UL1TR001881-01S2), RCUK | Defining the genetic cont... (G1000861), NIH | Identifying Genetic Deter... (5R01HL113264-04), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095161-000), NIH | Genetic and Genomic Chara... (1R01HL135142-01A1), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095164-002), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095168-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095162-000), NIH | Wake forest Clinical and ... (1UL1TR001420-01),...

    <p>RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association impli...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Tomkova, Marketa; Tomek, Jakub; Kriaucionis, Skirmantas; Schuster-Böckler, Benjamin;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT , RCUK | Determining the contribut... (BB/M001873/1), RCUK | Life Sciences Interface D... (EP/F500394/1)

    <jats:title>ABSTRACT</jats:title><jats:p>DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures – each representing a mutagenic process – derived from 30...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Sá, TH; Duran, AC; Tainio, Marko; Monteiro, CA; Woodcock, James;
    Project: WT , RCUK | Centre for Diet and Activ... (MR/K023187/1)

    The purpose of the study was to describe cyclists and cycling trips, and to explore correlates, time trends and health consequences of cycling in São Paulo, Brazil from 1997 to 2012. Cross-sectional analysis using repeated São Paulo Household Travel Surveys (HTS). At al...

  • publication . Article . 2020
    Open Access English
    Authors:
    Sarah E Jackson; Jamie Brown; Lion Shahab; Andrew Steptoe; Daisy Fancourt;
    Publisher: BMJ Publishing Group
    Project: RCUK | MARCH: Social, Cultural a... (ES/S002588/1), WT | Arts, Society and Public ... (205407), WT

    <jats:sec><jats:title>Background</jats:title><jats:p>This study aimed to examine associations between smoking and COVID-19 relevant outcomes, taking into account the influence of inequalities and adjusting for potential confounding variables.</jats:p></jats:sec><jats:se...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Adam Mead; Alya Zriwil; Sten Eirik Waelgaard Jacobsen; Roy Drissen; Supat Thongjuea; Petter S. Woll; Alice Giustacchini;
    Project: RCUK | Weatherall Institute of M... (G0902418), WT | Advanced FACS equipment f... (087371), RCUK | Cellular mechanisms of ha... (MC_UU_12009/7), RCUK | Strategic Skills Award (G0701761), RCUK | Transcriptional regulatio... (G0900892), RCUK | Understanding cell fate d... (MC_UU_12009/5)

    According to current models for hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs; Lin<sup>–</sup> Sca-1<sup>+</sup> c-Kit<sup>+</sup> CD34<sup>+</sup> Flt3<sup>hi</sup>) and common myeloid progenitors (CMPs; Lin<sup>–</sup> Sca- 1<sup>+</sup> c-Kit<sup>+</...

  • publication . Article . 2012
    Open Access English
    Authors:
    Angela Brueggemann; Thien Ho; Eleni Giannoulatou; Tanya Golubchik; Peter Donnelly;
    Project: WT | Pneumococcal evolution by... (083511), WT | Understanding the genetic... (090532), WT | Pneumococcal vaccine esca... (079126), WT | Modernising Medical Micro... (087646), RCUK | MODERNISING MEDICAL MICRO... (G0800778)

    Streptococcus pneumoniae ('pneumococcus') causes an estimated 14.5 million cases of serious disease and 826,000 deaths annually in children under 5 years of age. The highly effective introduction of the PCV7 pneumococcal vaccine in 2000 in the United States provided an ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Jennifer Crinion; Katerina Pappa; Alexander Leff;
    Publisher: Oxford University Press
    Project: WT | Mechanisms underlying spo... (106161), RCUK | Brain mechanisms underlyi... (MR/K022563/1)

    Abstract Central alexia is an acquired reading disorder co-occurring with a generalized language deficit (aphasia). We tested the impact of a novel training app, ‘iReadMore’, and anodal transcranial direct current stimulation of the left inferior frontal gyrus, on word ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Thomas Connor; Robert Kingsley; Andrew Page; Priscilla Branchu; Antonia Anna Lettini;
    Publisher: HAL CCSD
    Project: WT , RCUK | Molecular basis of foodbo... (BB/M025489/1), WT | Wellcome Trust Sanger Ins... (098051)

    Microevolution resulted in considerable genotypic variation.

8,483 research outcomes, page 1 of 849
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