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2,361 research outcomes, page 1 of 237
  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Balreira, Andrea; Boczonadi, Veronika; Barca, Emanuele; Pyle, Angela; Bansagi, Boglarka; Appleton, Marie; Graham, Claire; Hargreaves, Iain P; Rasic, Vedrana Milic; Lochmüller, Hanns; ...
    Publisher: Springer Nature
    Project: RCUK | Molecular mechanism of th... (G1000848), NIH | Mining the North American... (3U54NS078059-08S1), EC | RD-CONNECT (305444), EC | NEUROMICS (305121), EC | REVERSIBLECOX (309548), NIH | Molecular Pathogenesis an... (5R01HD056103-02), NIH | Molecular Pathogenesis of... (3R01HD057543-04S1), NIH | Investigating the pathoge... (5K23HD065871-05), WT | Mitochondrial DNA - expre... (096919)

    Inherited ataxias are heterogeneous disorders affecting both children and adults, with over 40 different causative genes, making molecular genetic diagnosis challenging. Although recent advances in next-generation sequencing have significantly improved mutation detectio...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Rhys A. Farrer; An Martel; Elin Verbrugghe; Amr Abouelleil; Richard Ducatelle; Joyce E. Longcore; Timothy Y. James; Frank Pasmans; Matthew C. Fisher; Christina A. Cuomo;
    Project: NIH | Large Scale Sequencing an... (3U54HG003067-07S1), WT , RCUK | The spatial epidemiology ... (NE/K012509/1)

    To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species...

  • publication . Other literature type . 2014
    Open Access
    Authors:
    Singer, Andrew;
    Publisher: figshare
    Project: RCUK | Pharmaceutical Release in... (NE/F009216/1), EC | EPIWORK (231807), EC | EPIFOR (204863), NIH | EpiC: A Cyberinfrastructu... (5R21DA024259-03), NWO | Microbial functioning of ... (2300134998), EC | DYNANETS (233847)

    Background: The global public health community has closely monitored the unfolding of the 2009 H1N1 influenza pandemic to best mitigate its impact on society. However, little attention has been given to the impact of this response on the environment. Antivirals and anti...

  • publication . Article . 2012
    Open Access English
    Authors:
    Oczypok, Elizabeth A.; Etheridge, Timothy; Freeman, Jacob; Stodieck, Louis; Johnsen, Robert; Baillie, David; Szewczyk, Nathaniel J.;
    Publisher: Royal Society, The
    Project: NIH | Gene Networks Regulating ... (7R01AR054342-02), RCUK | A genetic model for under... (G0801271)

    The ultimate survival of humanity is dependent upon colonization of other planetary bodies. Key challenges to such habitation are (patho)physiologic changes induced by known, and unknown, factors associated with long-duration and distance space exploration. However, we ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    robert carson;
    Project: EC | CDS-QUAMRI (634541), NIH | Institutional Predoctoral... (5T32EB014841-03), NIH | The Role of TSC Genes Dur... (5K08NS050484-02), NIH | A 15 Tesla MRI and MRS Sy... (1S10RR029523-01), RCUK | Direct Measurements of Mi... (EP/G007748/1), NIH | Sub-voxel Tissue Characte... (5R01EB001744-03), RCUK | Medical image computing f... (EP/M020533/1), NIH | Mapping the Human Connect... (3U54MH091657-03S1), RCUK | A biophysical simulation ... (EP/N018702/1)

    AbstractThis paper introduces a multi-compartment model for microscopic diffusion anisotropy imaging. The aim is to estimate microscopic features specific to the intra- and extra-neurite compartments in nervous tissue unconfounded by the effects of fibre crossings and o...

  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Ross McManus; Sarah Hunt; Elvira Grandone; Panos Deloukas; Graham A Heap; Jeffrey Barrett; Katherine Irene Morley; Alexandra Zhernakova; Bozena Cukrowska; Gosia Trynka; ...
    Publisher: Springer Science and Business Media LLC
    Project: WT | Extended genome wide asso... (084743), NWO | Identifying causative cop... (2300159001), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), WT | WTCCC2 core activities (085475), RCUK | Functional investigation ... (G0700545), EC | COPACETIC (201379)

    We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 control...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    sara garbarino; Jonathan Schott; Frederik Barkhof; M. Arfan Ikram;
    Publisher: eLife Sciences Publications, Ltd
    Project: EC | EuroPOND (666992), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Medical image computing f... (EP/M020533/1), CIHR

    <jats:p>The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approa...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Rebecca C. Richmond; Emma L. Anderson; Hassan S. Dashti; Samuel E. Jones; Jacqueline M. Lane; Linn Beate Strand; Ben Brumpton; Martin Rutter; Andrew R. Wood; Caroline L. Relton; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Epigenetic Epidemiology (MC_UU_00011/5), RCUK | Pleiotropy robust Mendeli... (MC_UU_00011/2), RCUK | Causes, Consequences and ... (MC_UU_00011/7), CIHR , RCUK | Epigenetics: Environment,... (ES/N000498/1), RCUK | Reproductive and cardio-m... (MC_UU_00011/6), EC | B-CAST (633784), EC | COGS (223175), EC | GLUCOSEGENES (323195), RCUK | Identifying non-coding mu... (MR/M005070/1),...

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To examine whether sleep traits have a causal effect on risk of breast cancer.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Multivariable regression, one- and two...

  • publication . Article . 2016
    Open Access
    Authors:
    Sean Clouston;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), NIH | Health Conditions, Biomar... (1P01AG043362-01), RCUK | Life course determinants ... (MC_UU_12019/4)

    Abstract Objective social inequalities in health are believed to arise in part because individuals make use of social and economic resources in order to improve survival. In recent years, health literacy has received increased attention as a factor that can help explain...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Julian Richard Naglik; Jonathan Richardson;
    Publisher: MDPI
    Project: NIH | Host and Fungal Regulatio... (5R37DE022550-07), RCUK | Mechanism of EGFR activat... (MR/M011372/1), RCUK | Candidalysins: Mechanisti... (BB/N014677/1)

    A plethora of intricate and dynamic molecular interactions occur between microbes and the epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species of Candida, are commensal members of our microbiota, continuously interacting with ep...

2,361 research outcomes, page 1 of 237
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