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463 research outcomes, page 1 of 47
  • publication . Article . 2015
    Open Access
    Authors:
    Jane Davies; Onn Min Kon; Amelia Shoemark; Sebastian Johnston;
    Publisher: Elsevier BV
    Project: RCUK | Mechanisms of Deficient I... (G0601236), RCUK | MRC-Asthma UK Centre in A... (G1000758), EC | MORIAE (233015), NHMRC | Molecular Regulation of B... (1016647), NHMRC | Molecular Regulation of B... (461219), EC | PREDICTA (260895), WT

    Background Rhinovirus infections are the dominant cause of asthma exacerbations, and deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic patients are un...

  • publication . Article . Conference object . 2018
    Open Access English
    Authors:
    Rosie Walker; Kathryn L Evans; Mairead L. Bermingham; Qian Zhang; Riccardo Marioni; Daniel McCartney; Robert Hillary; Andrew M McIntosh; Anna Stevenson;
    Publisher: BioMed Central
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1), NHMRC | Neurogenetics and Statist... (1078037), NHMRC | Inheritance of DNA methyl... (1010374), NHMRC | Complex trait genomics (1113400), WT , NHMRC | Using genomics to underst... (1078901), WT | Stratifying Resilience an... (104036), NHMRC | Genetics of DNA Methylati... (1083656), NHMRC | CAGE: Consortium for the ... (1046880)

    Background Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors for a multitude of traits and diseases. Such predictors may be more accurate than the self-reported phenotypes and could have clinical applications. Results H...

  • publication . Article . 2013
    Open Access English
    Authors:
    Michael Cousin; Karen Smillie;
    Publisher: Nature Pub. Group
    Project: WT | Activity-dependent contro... (084277), RCUK | Aberrant protein phosphor... (G1002117), NHMRC | Colon cancer and transcri... (1002117)

    Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotr...

  • publication . Article . 2020
    Open Access English
    Publisher: BMJ Publishing Group
    Project: WT , NHMRC | Integrate, Identify, Inte... (1045668), RCUK | Centre for Health service... (MR/K006584/1)
  • publication . Other literature type . Conference object . Article . 2015
    Open Access
    Authors:
    David Ascher; Harry Jubb;
    Publisher: Elsevier BV
    Project: NHMRC | Development of small mole... (1072476), RCUK | Understanding and Modulat... (BB/J500574/1), WT

    AbstractThe transient assembly of multiprotein complexes mediates many aspects of cell regulation and signalling in living organisms. Modulation of the formation of these complexes through targeting protein–protein interfaces can offer greater selectivity than the inhib...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Michael Clark; Paul Harrison; Nicola Hall;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Brain-enriched voltage-ga... (MR/P026028/1), NHMRC | Discovery and characteris... (1072662), WT | Capture NanoporeSeq: A no... (201879)

    <jats:title>Abstract</jats:title><jats:p>RNA splicing is a key mechanism linking genetic variation with psychiatric disorders. Splicing profiles are particularly diverse in brain and difficult to accurately identify and quantify. We developed a new approach to address t...

  • publication . Article . Conference object . 2014
    Open Access English
    Authors:
    Cecilia Lindgren; André Scherag; Åsa Hedman; Marcus E. Kleber; Stuart MacGregor; Grant W Montgomery; Nicholas G Martin; Dale R Nyholt; Krina Zondervan; Inga Prokopenko;
    Project: NHMRC | Statistical methods for i... (613705), NHMRC | Research Fellowship - Gra... (442915), RCUK | Genetic and transcription... (MR/K011480/1), NHMRC | Research Fellowship - Gra... (339446), NHMRC | Genetics of melanoma risk... (389875), WT | The genetics of weight, B... (076113), NHMRC | Mapping Genes for typical... (389938), NHMRC | Genome-wide combined link... (389891), NHMRC | Statistical Methods and A... (389892), WT | Genome wide association s... (084766),...

    <p>Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide ass...

  • publication . Article . 2016
    Open Access English
    Authors:
    Yuming Guo; Eric Lavigne; Paola Michelozzi; Masahiro Hashizume; Aurelio Tobías;
    Publisher: Oxford University Press (OUP)
    Project: ARC | From science to policy: q... (DP110100651), RCUK | A multi-country analysis ... (MR/M022625/1), RCUK | A general conceptual and ... (G1002296), NHMRC | Uncoupled Research Fellow... (553043)

    Peer reviewed

  • publication . Other literature type . Article . 2018 . Embargo End Date: 16 Jul 2019
    Open Access
    Authors:
    Morris, John A; Kemp, John P; Youlten, Scott E; Laurent, Laetitia; Logan, John G; Chai, Ryan C; Vulpescu, Nicholas A; Forgetta, Vincenzo; Kleinman, Aaron; Mohanty, Sindhu T; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Identifying Osteoporosis ... (5R01AR072199-02), RCUK | Using Genetics to Identif... (MC_UU_12013/4), EC | GEFOS (201865), NIH | Skeletal Phenotyping of K... (5R01AR063702-05), NIH | Genomic organization of l... (5R35GM119703-03), CIHR , NIH | Risk Factors for Age Rela... (5R01AR041398-23), NIH | Genetics of Osteoblast Di... (5R21AR060981-02), NHMRC | Developing and applying s... (1137714)

    Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total of 518 genome-wide significant l...

  • publication . Article . Conference object . 2017
    Open Access English
    Authors:
    Jamie Flynn; David I Hughes; Brett Graham;
    Publisher: Frontiers Media S.A.
    Project: NHMRC | The role of presynaptic i... (1043933), NIH | Spinal cord neural circui... (5R01NS090919-04), NHMRC | Spinal mechanism underlyi... (631000), RCUK | Modulating cutaneous affe... (BB/J000620/1), NHMRC | Connectivity of regenerat... (628765)

    Long descending propriospinal neurons (LDPNs) are interneurons that form direct connections between cervical and lumbar spinal circuits. LDPNs are involved in interlimb coordination and are important mediators of functional recovery after spinal cord injury. Much of wha...

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