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352 research outcomes, page 1 of 36
  • publication . Article . 2016
    Open Access English
    Authors:
    Marrie, Ruth Ann; Miller, Aaron; Sormani, Maria Pia; Thompson, Alan; Waubant, Emmanuelle; Trojano, Maria; O'Connor, Paul; Reingold, Stephen; Cohen, Jeffrey A.;
    Publisher: Lippincott Williams & Wilkins
    Project: RCUK | Confidence in Concept 201... (MC_PC_12024), WT , CIHR

    Objective: We aimed to provide recommendations for addressing comorbidity in clinical trial design and conduct in multiple sclerosis (MS). Methods: We held an international workshop, informed by a systematic review of the incidence and prevalence of comorbidity in MS an...

  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Russell, Timothy W; Hellewell, Joel; Jarvis, Christopher I; van-Zandvoort, Kevin; Abbott, Sam; Ratnayake, Ruwan; Flasche, Stefan; Eggo, Rosalind M; Kucharski, Adam J; CMMID nCov working group;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Real-time modelling for f... (210758), RCUK | GCRF: RECAP - Research ca... (ES/P010873/1), WT | Immunity dynamics and epi... (206250), CIHR , WT | Using mathematical modell... (208812)

    <jats:p>Adjusting for delay from confirmation-to-death, we estimated case and infection fatality ratios (CFR, IFR) for COVID-19 on the Diamond Princess ship as 2.3% (0.75%-5.3%) and 1.2% (0.38-2.7%). Comparing deaths onboard with expected deaths based on naive CFR estim...

  • publication . Article . Other literature type . 2010
    Open Access English
    Authors:
    Robert Hogg; Jonathan Sterne; Matthias Egger; Michael John Gill; Dominique Costagliola; Margaret May;
    Publisher: OXFORD UNIV PRESS INC
    Project: RCUK | Dealing with missing data... (G0600599), CIHR

    BACKGROUND: We examined specific causes of mortality in human immunodeficiency virus type 1 (HIV-1)-infected patients who initiated antiretroviral therapy (ART) in Europe and North America from 1996 through 2006, and we quantified associations of prognostic factors with...

  • publication . Article . 2019
    Open Access English
    Authors:
    Malcolm, Janice C.; Breuillaud, Lionel; Do Carmo, Sonia; Hall, Hélène; Welikovitch, Lindsay A.; Macdonald, Jennifer A.; Goedert, Michel; Cuello, A. Claudio;
    Publisher: Academic Press
    Project: RCUK | Molecular mechanisms of n... (MC_U105184291), CIHR

    The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. Several murine models ...

  • publication . Article . 2015
    Open Access
    Authors:
    Pr, Burton; Mj, Murtagh; Andy Boyd; Jb, Williams; Es, Dove; Se, Wallace; Am, Tassé; Little J; Rl, Chisholm; Gaye A; ...
    Project: RCUK | MICA: The Scottish eHealt... (MR/K007017/1), WT | Influences on psychosocia... (086118), EC | BIOSHARE-EU (261433), EC | BBMRI-LPC (313010), WT | The Avon Longitudinal Stu... (102215), CIHR

    Motivation: The data that put the ‘evidence’ into ‘evidence-based medicine’ are central to developments in public health, primary and hospital care. A fundamental challenge is to site such data in repositories that can easily be accessed under appropriate technical and ...

  • publication . Article . Other literature type . Conference object . 2017
    Open Access English
    Authors:
    Stéphane Martin; Jeremy Henley; Steven A. Goldstein; Kevin Wilkinson;
    Publisher: HAL CCSD
    Project: NIH | SUMOylation and Amyloid-b... (5R01NS049442-09), RCUK | Roles of protein SUMOylat... (MR/L003791/1), WT | Role of Protein SUMOylati... (200581), CIHR

    A commentary on\ud Analysis of SUMO1-conjugation at synapses\ud \ud by Daniel, J. A., Cooper, B. H., Palvimo, J. J., Zhang, F. P., Brose, N., and Tirard, M. (2017). eLife 6:e26338. doi: 10.7554/eLife.26338\ud \ud There is a large and growing literature on protein SUMOyl...

  • publication . Other literature type . Article . 2018 . Embargo End Date: 16 Jul 2019
    Open Access
    Authors:
    Morris, John A; Kemp, John P; Youlten, Scott E; Laurent, Laetitia; Logan, John G; Chai, Ryan C; Vulpescu, Nicholas A; Forgetta, Vincenzo; Kleinman, Aaron; Mohanty, Sindhu T; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Identifying Osteoporosis ... (5R01AR072199-02), RCUK | Using Genetics to Identif... (MC_UU_12013/4), EC | GEFOS (201865), NIH | Skeletal Phenotyping of K... (5R01AR063702-05), NIH | Genomic organization of l... (5R35GM119703-03), CIHR , NIH | Risk Factors for Age Rela... (5R01AR041398-23), NIH | Genetics of Osteoblast Di... (5R21AR060981-02), NHMRC | Developing and applying s... (1137714)

    Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total of 518 genome-wide significant l...

  • publication . Conference object . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Roberta Ghidoni; Daniela Galimberti; Kejal Kantarci; Giacomina Rossi; Sebastian Crutch; Giuliano Binetti; Anton Porsteinsson; Laura L. Boles Ponto; Giorgio Giulio Fumagalli; James Rowe; ...
    Project: WT | Restoring brain function:... (103838), RCUK | Developing an evidence ba... (MR/M008525/1), RCUK | Computational models of n... (EP/J020990/1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | EuroPOND (666992), RCUK | Medical image computing f... (EP/M020533/1), RCUK | UK Dementias Platform (MR/L023784/1), RCUK | Seeing what they see: com... (ES/L001810/1), CIHR

    Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and d...

  • publication . Conference object . Article . 2017
    Open Access
    Authors:
    Sharon Walmsley; Marina Klein; Daniel J Corsi; Fabiola Martin; Caroline Sabin; Douglas Lee; Jane Anderson; Clare Liddy;
    Project: NIH | Seek and Treat for Optima... (5DP1DA026182-05), RCUK | The clinical outcomes, re... (G0900274), RCUK | The uses and outcomes of ... (G0600337), CIHR

    OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 y...

  • publication . Article . 2017
    Open Access English
    Authors:
    Cristina Razquin; Roberta Ghidoni; Giacomina Rossi; Gianluigi Forloni; stefano cappa; valeria novelli; Agustín Ruiz Laza; Danielle Posthuma; DIEGO ALBANI; James Rowe; ...
    Project: CIHR , NHMRC | Investigation of dysfunct... (630428), NHMRC | Improving diagnosis of ea... (1022684), NIH | Characterization of Norma... (1ZIAAG000932-04), NIH | FRONTOTEMPORAL DEMENTIA: ... (5P01AG019724-03), NIH | Translational Neuroscient... (1P30NS069329-01), NIH | HEALTHY AGING AND SENILE ... (3P01AG003991-13S1), NIH | GGGGCC hexanucleotide rep... (4R01NS080882-05), NHMRC | Investigation of dysfunct... (1005769), NHMRC | Genetic Repositories Aust... (401184),...

    Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified only a few risk loci. One of the possible explanations is that FTD is clinically, pathologicall...

352 research outcomes, page 1 of 36
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